三种肾小球滤过率评估方程在中国慢性肾脏病患者的适用性评价

Applicability of Glomerular Filtration Rate Estimated with Three Equations in Chinese Patients with Chronic Kidney Disease

目的评价简化肾脏病膳食改良试验(MDRDa)方程以及国内两个改良MDRD方程(中国方程1、2)预测中国慢性肾脏病患者肾小球滤过率(glomerular filtration rate,GFR)的适用性。方法选择2008年1 12月住院慢性肾病患者250例,用99mTc-DTPA肾动态显像法测定GFR(sGFR),同时测定血清肌酐、尿素氮,根据年龄和性别分别用简化MDRD方程、中国方程1和中国方程2预测GFR,即eGFRa(简化MDRD方程)、eGFR1(中国方程1)和eGFR2(中国方程2),以sGFR为参考值,将估计的eGFRs进行比较。结果各方程eGFRs与sGFR之间呈显著相关关系。其中中国方程2的估算eGFR2与sGFR具有良好的一致性,总体偏差最小,准确性最高。结论中国方程2优于简化MDRD方程和中国方程1,可用于中国慢性肾病人群eGFR的计算。

Objective To evaluate the applicability of three equations for glomerular filtration rate（GFR） in Chinese patients with chronic kidney disease（CKD）.Methods A total of 250 patients with CKD which were diagnosed according to K/DAQI guidelines between January and December 2008 were selected.GFR were estimated with Chinese equation 1（eGFR1）,Chinese equation 2（eGFR2） and abbreviated MDRD（eGFRa） separately,and the results were compared with that of 99mTc-DTPA（sGFR）.Results The eGFRs of the three equations were correlated significantly with sGFR.Chinese equation 2 seemed to be the best;eGFR2 showed less bias and higher accuracy than other equations.Conclusions Chinese equation 2 for estimation of GFR may be more accurate in Chinese CKD patients