葡萄糖转运蛋白Ⅰ型与肿瘤增殖细胞核抗原在卵巢上皮性肿瘤中的表达及意义

Expression and Significance of Glucose Transporter 1 and Tumor Proliferating Karyon Antigen Ki-67 in Epithelial Ovarian Tumor

目的探讨葡萄糖转运蛋白Ⅰ型(glucose transporter 1,GLUT1)和肿瘤增殖细胞核抗原Ki-67在卵巢上皮性肿瘤组织中的表达及其临床意义。方法收集2000年1月2008年6月不同卵巢上皮性肿瘤病变患者119例的组织标本,采用免疫组织化学SP二步法检测肿瘤组织中GLUT1和Ki-67的表达情况。结果卵巢交界性、恶性上皮性肿瘤灶性或广泛高表达GLUT1和Ki-67,其表达强度有差异。卵巢良性上皮性肿瘤不表达GLUT1和Ki-67。在卵巢癌中GLUT1及Ki-67的表达强度与病理分级、临床分期、预后有关。GLUT1表达强度与病理分型无关,Ki-67表达强度与病理分型有关。结论卵巢上皮性肿瘤组织中GLUT1和Ki-67的表达具有相关性,其表达强度与肿瘤的良恶性质和增殖状态有关,二者同时检测可以全面了解卵巢上皮性肿瘤的性质、卵巢癌恶性程度和生物学行为,对于判断肿瘤的性质和预后有一定价值。

Objective To investigate the expression and clinical significance of glucose transporter-1（GLUT1） and tumor proliferating karyon antigen Ki-67 in epithelial ovarian tumor tissue.Methods Immunohistochemistry SP method was used to detect the expression of GLUT1 and Ki-67 protein in epithelial ovarian tumor tissues from 119 patients diagnosed in our hospital from January 2000 to June 2008.Results The expressions of GLUT1 and Ki-67 had local or abroad higher expressions in the borderline and malignant epithelial ovarian tumor,and the expressive intensity was different.In benign tumors,the expression was negative.The expressive intensity of GLUT1 and Ki-67 had correlation with the grade,stage,and prognosis in malignant tumors.The expressive intensity of GLUT1 had no correlation with the type of malignant tumors,while Ki-67 related to the pathological types.Conclusion The expressions of GLUT1 and Ki-67 have relativity.The expressive intensity of GLUT1 and Ki-67 relates to the character and proliferation of epithelial ovarian tumors.The combined detection GLUT1 and Ki-67 is helpful to know the character of epithelial ovarian tumors,the malignant degree and biologic behavior of ovarian carcinoma,which is useful in estimating the character and prognosis of epithelial ovarian tumors.