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脑深部电刺激对帕金森病认知功能的影响 被引量：2

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摘要 帕金森病(Parkinson's disease,PD)是中老年人常见的神经系统变性疾病。脑深部电刺激(deep brainstimulation,DBS)可以改善中晚期或药物难治性PD患者的运动症状、生活质量,并且丘脑底核脑深部电刺激(subthalamic nucleus deep brain stimulation,STN DBS)还可减少术后多巴胺能药物的治疗剂量,但DBS术后同时可出现认知功能、行为、情绪和精神等方面的变化。目前DBS对认知功能如语言功能、执行功能、记忆力、注意力、视功能和精神运动速度等方面的影响尚无一致的结论,现就DBS对认知功能各方面的影响进行综述。
作者 李楠楠 袁强 彭蓉
机构地区 四川大学华西医院神经内科
出处 《华西医学》 CAS 2011年第1期129-132,共4页 West China Medical Journal
关键词 帕金森病 认知功能 脑深部电刺激
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献29

  • 1Silberstein P, Bittar RG, Boyle R, et al. Deep brain stimulation for Parkinson's disease: Australian referral guiclelines[J]. J Clin Neurosci, 2009, 16(8) : 1001-1008.
  • 2Gaspair DD, Siri C, Gioia MD, et al. Clinical correlates and cognitive underpinnings of verbal fluency impairment after chronic subthalamic stimulation in Parkinson's disease [J]. Parkinsonism Relat Disord, 2006, 12(5): 289 -295.
  • 3Parsons TD, Rogers SA, Braaten AJ, et al. Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: a meta-analysis[J]. Lancet Neurol, 2006, 5 (7): 578- 588.
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同被引文献31

  • 1王乔树,赵永波,孙伯民,王晓平.双侧丘脑底核电刺激对帕金森病患者生活质量影响的研究[J].中国神经精神疾病杂志,2005,31(4):256-259. 被引量：5
  • 2刘海鹏,杨辉,孙伯民,周政,黄其林,安宁,刘俊,何家全,马志国.帕金森病患者脑深部电刺激治疗后神经行为变化[J].中国行为医学科学,2005,14(10):920-920. 被引量：1
  • 3Dormont D, Seidenwurm D, Galanaud D,et al.Neuroimaging and deep brain stimulation[J].AJNR Am J Neuroradiol,2010,31 (1):15.
  • 4Minamimoto T, Hori Y, Kimura M. Roles of thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of action[J].Brain Research Bulletin,2009,78(2-3):75.
  • 5Galvan A,Smith Y.The primate thalamostriatal systems:Anatomi- cal organization,functional roles and possible involvement in Parkinson's disease[J].Basal Ganglia,2011,1(4):179.
  • 6Nambu A. Globus paliidus internal segment[J].Progress in Brain Research,2007,160:135.
  • 7Bronstein JM,Tagliati M,Alterman RL,et al.Deep brain stimula- tion for Parkinson disease: an expert consensus and review ofkey issues[J].Arch Neurol,2011,68(2):165.
  • 8PaxinoS G, Watson C. The rat brain in stereotaxic coordinates [M]. 5th Edition. Electronic press,2005:71-88,89-90.
  • 9骞健,张巧俊-巾自金森病大鼠模型海马mGluR5的表达变化及意义[J].中西医结合心脑血管疾病杂志,2010,8(1):65.
  • 10Paxinos G, Watson C. The rat brain in stereotaxic coordinates [M]. 5th Edition. Electronic press,2005.51-56,67-70.

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华西医学
2011年 第1期

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