摘要
目的孤立性肺结节(solitary pulmonary nodule,SPN)的定性诊断十分困难,PET/CT是目前评价良、恶性病变最具优势的影像学手段之一。文中用Meta分析方法综合评价18F-脱氧葡萄糖(18Fluorodexglucose,FDG)PET/CT显像诊断恶性孤立性肺结节的价值。方法以孤立性肺结节、FDG、PET/CT等为检索词,检索1994年1月至2009年7月的Medline数据库、西文生物医学期刊文献服务系统、外文生物医学期刊全文数据库、中国学术期刊网全文数据库等相关中英文文献。对符合标准的研究进行质量评估,用MetaDisc1.4软件进行异质性检验,综合敏感性、特异性和诊断优势比,绘制汇总受试者工作特征(summary receiver operating characteristic,SROC)曲线和计算曲线下面积(the area under the curve,AUC),并进行敏感性分析。结果共检索相关文献29篇,其中11篇符合标准纳入分析,A级1篇,B级10篇,各研究之间存在异质性,按照随机效应模型合并敏感性、特异性、诊断优势比(diagnostic odds ratio,DOR)及其95%可信区间分别为91%(87%~93%)、83%(78%~87%)和51.04(23.33~111.66),AUC为0.9383,Q值为0.875 3,纳入文献稳定性较好。结论 18F-FDG PET/CT显像能灵敏、准确地诊断恶性孤立性肺结节,具有较高的临床应用价值。
Objective Solitary pulmonary nodules are very difficult to be diagnosed correctly.PET/CT is the most advanced imaging methods for the differentiation of benign from malignant disease.The authors present a Meta-analysis on the value of 18F-FDG PET/CT in the diagnosis of solitary pulmonary nodules.Methods We searched English and Chinese literature for relevant publications using the
出处
《医学研究生学报》
CAS
2011年第1期39-42,共4页
Journal of Medical Postgraduates
基金
南京军区南京总医院科研基金(2010M009)
关键词
孤立性肺结节
脱氧葡萄糖
正电子发射型计算机断层扫描
计算机体层扫描
META分析
＂solitary pulmonary nodule＂
＂FDG＂
and ＂PET/CT＂
evaluated the quality of the identified studies
and conducted a heterogenety test with the MetaDisc 1.4 software.Then we measured the sensitivity
specificity and diagnostic odds ratio（DOR）
drew a summary receiver operating characteristic（SROC） curve
calculated the area under the curve（AUC）
and finally performed a sensitivity analysis.Results Eleven of the twenty-nine identified studies were eligible for this Meta-analysis.Because of the heterogeneity among the included articles
a proper effect model was selected to calculate the pooled sensitivity（91%
87%-93%）
specificity（83%
78%-87%） and DOR（51.04
23.33-111.66） with 95% confidence intervals.The area under the SROC curve was 0.938 3 and the Q index was 0.875 3.Conclusion 18F-FDG PET/CT is considerably favorable for clinical application in the diagnosis of malignant solitary pulmonary nodules with high sensitivity and accuracy.Key words：Solitary pulmonary nodule
Deoxyglucose
Positron emission tomography
Computed tomography
Meta-analysis
