期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

尿酸在慢性肾病发展中的作用 被引量：12

The role of serum uric acid in the progression of chronic kidney disease
下载PDF
导出
摘要 高尿酸血症(hyperuricemia,HUA)是肾功能减退的表现之一,在慢性肾病(chron ic k idney d isease,CKD)的发生、发展中起着促进作用。最近的基础及临床研究进一步揭示了其在CKD进展中的作用,文中对此作一综述,旨在指导临床通过改善高尿酸水平,从而延缓CKD进展。 Elevated serum uric acid is a marker for decreased renal function,and have a mechanistic role in the incidence and progression of chronic kidney disease（CKD）.Recent experimental models and clinical trials have suggested its important role in the progression of CKD.The purpose of this review is to assess the current data,aiming at proving the effect of uric acid-losing therapy in the prevention of CKD.
作者 张希燃 王庆文
机构地区 南京大学医学院临床学院(南京军区南京总医院)解放军肾脏病研究所
出处 《医学研究生学报》 CAS 2011年第1期105-108,共4页 Journal of Medical Postgraduates
关键词 尿酸 慢性肾病 危险因素 Uric acid Chronic kidney disease Risk factor
分类号 R692 [医药卫生—泌尿科学]
  • 相关文献

参考文献39

  • 1Feig DI,Soletsky B,Johnson RJ.Effect of allopurinol on blood pressure of adolescents with newly diagnosed essential hypertension:A randomized trial[J].JAMA,2008,300(8):924-932.
  • 2Feig DI,Kang DH,Johnson RJ.Uric acid and cadiovascular risk[J].N Ehgl J Med,2008,359(13):1811-1821.
  • 3Johnson RJ,Perez-Pozo SE,Sautin YY,et al.Hypothesis:Could excessive fructose intake and uric acid cause type 2 diabetes?[J] Endocr Rev,2009,30(1):96-116.
  • 4Wu X,Wakamiya M,Vaishnav S,et al.Hyperuricemia and urate nephropathy in urate oxidase-deficient mice[J].Proc Natl Acad Sci USA,1994,91(6):742-746.
  • 5Sanchez-Lozada LG,Apia ES,Jherrera-Acosta J.Mild hyperuricemia increases arteiolopathy inducing renal cortical ischemia in 5/6 nephrectomy rats[J].J Am Soc Nephrol,2003,13(12):2888-2897.
  • 6Mazzali M,Hughes J,Kim YG,et al.Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism[J].Hypertension,2001,38(5):1101-1106.
  • 7Corry DB,Eslami P,Yamamoto K,et al.Uric acid stimulates vascular smooth muscle cell proliferation and oxidative stress via the vascular renin-angiotensin system[J].J Hypertens,2008,26(2):269-275.
  • 8Mazzali M,Kanellis J,Han L,et al.Hyperuricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism[J].Am J Physiol Renal Physiol,2002,282(8):F991-F997.
  • 9Sanchez-Lozada LG,Tapia E,Soto V,et al.Effect of febuxostat on the progression of renal disease in 5/6 nephrectomy rats with and without hyperuricemia[J].Nephron Physiol,2008,108(1):69-78.
  • 10Mazzali M,Kanellis J,Han L,et al.Hyperuricemia induces a primary arteriolopathy in rats by a blood pressure-independent mechanism[J].Am J Phyiol Renal Physiol,2002,282(7):991-997.

二级参考文献32

  • 1汪俊军,张春妮.胆固醇酯转运蛋白基因变异与血脂和动脉粥样硬化性心血管病的关系[J].医学研究生学报,2007,20(1):76-79. 被引量：17
  • 2王霞娟,卜瑞芳,邓振霞.醛固酮与糖尿病及其慢性并发症的关系[J].医学研究生学报,2007,20(5):548-552. 被引量：14
  • 3Muggeo M, Bolli G, Bompiani G, et al. Glycemic control and cardiovascular diseases in Type 2 diabetes mellitus. Beyond fasting glycemia and glycosylated hemoglobin [ J ]. Diabetes Nutr Metab ,2000,13 (4) : 182-185.
  • 4Crook ED, Patel S. Glycemic control predicts diabetic extrarenal microvascular complications but not renal survival in patients with moderate to severe chronic kidney disease [ J ]. Ethn Dis,2006, 16(4) :865-871.
  • 5Lubowsky ND, Siegel R, Pittas AG. Management of glycemia in patients with diabetes mellitus and CKD[J]. Am J Kidney Dis, 2007, 50(5) : 865-879.
  • 6Okada T, Nakao T, Matsumoto H, et al. Association between markers of glycemic control, cardiovascular complications and survival in type 2 diabetic patients with end-stage renal disease [J]. Intern Med, 2007, 46(12) :807-814.
  • 7Sechi LA, Catena C, Zingaro L, et al. Abnormalities of glucose metabolism in patients with early renal failure [ J ]. Diabetes, 2002, 51(4) : 1226-1232.
  • 8Little RR, Tennill AL, Rohlfing C, et al. Can glycohemoglobin be used to assess glycemic control in patients with chronic renal failure? [J] Clin Chem, 2002, 48(5) : 784-786.
  • 9Krepinsky J, Ingram A J, Clase CM. Prolonged sulfonylurea-induced hypoglycemia in diabetic patients with endstage renal disease[J]. Am J Kidney Dis,2000,35(3) :500-505.
  • 10Nathan DM, Buse JB, Davidson MB, et al. Management of hyperglycemia in type 2 diabetes : a consensus algorithm for the initiation and adjustment of therapy : a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes [ J ]. Diabetes Care, 2006,29 ( 8 ) : 1963- 1972.

共引文献9

同被引文献117

引证文献12

二级引证文献55

医学研究生学报
2011年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部