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microRNA在肾脏疾病中的研究进展

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摘要 microRNA(miRNA)作为一种新的基因表达调控因子,与以往的各类小RNA及蛋白质酶相比,无论是产生还是作用机制上,都有其独到的特点。miRNA能够与靶mRNA3-UTR区的碱基互补配对而起作用,使其降解或抑制其表达,从而导致特定基因沉默,对机体生长、
出处 《临床肾脏病杂志》 2011年第1期44-46,共3页 Journal Of Clinical Nephrology
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参考文献20

  • 1李莉,温旺荣,朱晴晖.微小RNA及其表达水平检测方法的研究进展[J].检验医学,2009,24(4):316-320. 被引量:10
  • 2Harfe BD.MiRNAs in vertebrate development.Curr Opin Genet Dev,2005,15:410-415.
  • 3Xi Y,Shalgi R,Fodstad O,et al.Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancer.Clin Cancer Res,2006,12:2014-2024.
  • 4Obernosterer G,Leuschner PJ,Alenius M,et al.Post-transcriptional regulation of miRNA expression.RNA,2006,12:1161-1167.
  • 5van den Akker E,Ano S,Shih HM,et al.FLI-1 functionally interacts with PIASxalpha,a member of the PIAS E3 SUMO ligase family.J Biol Chem,2005,280:38035-38046.
  • 6Khokon KD,Yi Zh,Yu-Ting L,et al.Association of miRNA -34a overexpression with proliferation is cell type-dependent.Cancer Sci,2007,98:1845-1852.
  • 7Nakada C,Matsuura K,Tsukamoto Y,et al.Genome-wide miRNA expression profiling in renal cell carcinoma:Significant down-regulation of miR-141 and miR-200c.J Pathol.2008,216:418-427.
  • 8Iwai N,Naraba H.Polymorphisms in human pre-miRNAs.Biochem Biophys Res Commun.2005,17:331:1439-444.
  • 9Duan R,Pak C,Jin P.Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA.Hum Mol Genet.2007,16:1124-1131.
  • 10Horikawa Y,Wood CG,Yang H,et al.Single nucleotide polymorphisms of miRNA machinery genes modify the risk of renal cell carcinoma.Clin Cancer Res,2008,14:7956-7962.

二级参考文献20

  • 1孙凯,黄晓卉,甄茂川,汪谦.应用液相芯片分析肝细胞癌及癌旁组织小分子RNA表达谱差异[J].中华实验外科杂志,2006,23(8):945-947. 被引量:25
  • 2Schmittgen TD, Lee E J, Jiang J, et al. Real-time PCR quantification of precursor and mature microRNA[ J]. Methods ,2008,44( 1 ): 31-38.
  • 3Tang F, Hajkova P, Barton SC, et al. MicroRNA expression profiling of single whole embryonic stem cells [ J ]. Nucleic Acids Res,2006,34 ( 2 ) : 1-7.
  • 4David D,Eshoo DM, Esau C, et al. Absolute quantitation of microRNAs with a PCR-based assay[ J]. Anal Biochem,2006,359 : 268-270.
  • 5Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-dencodes small RNAs with antisense complementarity to lin-14[ J] . cell, 1993,75 (5) :843-854.
  • 6Soraya Yekta, I-hung Shih, David P. Bartel. MicroRNA-Directed Cleavage of HOXB8 mRNA [ J ]. Science ,2004,304 ( 5670 ) : 594-596 .
  • 7Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers [ J ]. Nature, 2005, 435 (7043) : 834-838.
  • 8Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis [ J]. Cancer Cell, 2006,9 ( 3 ) : 189- 198.
  • 9Lowery A J, Miller N, McNeill RE,et al. MicroRNAsas prognostic indicators and therapeutic targets: potential effect on breast cancer management [ J ]. Clin Cancer Res. 2008 ; 14 (2) :360-365.
  • 10Krutzfeldt J, Rajewsky N, Braich R, et al. Silencing of microRNAs in vivo with'antagomirs'[J]. Nature , 2005,438 ( 7068 ) :685-689.

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