NF-κB和HPA在口腔鳞状细胞癌中的表达及意义

Expression and significance of NF-κB and HPA in oral squamous cell carcinoma

目的:应用组织微阵列技术,检测口腔鳞癌中核转录因子кB(NF-κB)和乙酰肝素酶(HPA)的表达,探讨两者之间的关系及其临床意义。方法:应用组织微阵列技术和免疫组化方法,检测146例口腔鳞癌、48例正常口腔黏膜中NF-κB和HPA的表达。应用SPSS13.0软件包对数据进行χ2检验和Spearman相关分析。结果:NF-κB和HPA在口腔鳞癌中的阳性表达率分别为69.2%和63.7%,显著高于正常口腔黏膜组(P<0.05)。NF-κB和HPA在口腔鳞癌中的表达与肿瘤的分化程度、临床分期和有无区域淋巴结或远处转移相关(P<0.05),而与患者性别、年龄、肿瘤发生部位无关(P>0.05)。NF-κB的表达与HPA的表达呈正相关(r=0.7301,P<0.05)。结论:NF-κB与HPA协同作用,促进口腔鳞癌的发生、发展。

PURPOSE：To detect the expression of NF-κB and HPA in oral squamous cell carcinoma（OSCC） by tissue microarray assay and investigate their clinical significance.METHODS：Tissue microarray assay and immunohistochemistry were applied to detect the expression of NF-κB and HPA in 146 cases of OSCC and 48 cases of normal control.Chi-square test and Spearman rank correlation were performed using SPSS 13.0 software package for statistics.RESULTS：The positive rates of NF-κB and HPA were 69.2% and 63.7%,respectively.There was significant difference compared with normal oral mucosa（P0.05）.The expression of NF-κB and HPA in OSCC was significantly correlated with histological differentiation,clinical stage and lymph node or distant metastasis（P0.05）,but not with sex and age of the patients or site of the tumor（P0.05）.The expression of NF-κB had a significant positive correlation with the expression of HPA in OSCC（r=0.7301,P0.05）.CONCLUSION：The expression of NF-κB and HPA may have synergistic effect on the carcinogenesis and progression of OSCC.