医用镁合金表面改性研究进展

Research progress on surface modification of magnesium alloys for medical applications

由于镁及其合金具有良好的生物相容性和力学相容性,降低镁合金过快的腐蚀速度成为其作为生物材料应用的关键,医用镁合金表面改性已成为新一代生物材料的研究重点。介绍医用镁合金的发展历程,重点讨论镁合金表面生物活性陶瓷(如羟基磷灰石(HA))、阳极氧化膜、可降解高分子聚合物(如聚乳酸(PLA)、PLGA、壳聚糖)、惰性生物陶瓷涂层(如TiO2、Al2O3、ZrO2)、化学转化膜(氟化膜、稀土转化膜)和金属镀层(如Ti、Zn)制备、耐蚀性及其生物相容性,并指出其发展趋势。

Magnesium and its alloys have excellent biocompatibility and mechanical compatibility.The reduction in their rapid corrosion rates becomes the key to clinical applications.The current study on magnesium alloys as biomaterials is focused on the surface modification.The history and recent cutting edge researches on the bio-coatings on medical magnesium alloys were predominately reviewed.The emphasis was placed on the recent progress of the preparation,corrosion resistance and biocompatibility of the bio-coatings.These coatings include hydroxyaptite（HA）,micro arc oxidation films or plasma electrolyte oxidation coatings,degradable polymers（polylactic acid（PLA）,poly（lactide-co-glycolide）（PLGA） and chitosan）,inert bio-ceramic coatings（TiO2,Al2O3 and ZrO2） and chemical conversion films（fluoride and rare earth） and ion implanted titanium and zinc films as well.The developmental trends were proposed.