摘要
目的探讨朊蛋白(PrPC)在胰腺癌组织中表达及其临床意义。方法应用免疫组织化学方法检测PrPC在胰腺癌及其对应正常胰腺组织的表达,分析其表达强度与性别、分化、临床分期及转移等临床病理资料之间的关系。结果PrPC在胰腺癌组织中和正常胰腺组织中的表达有显著差异;在高分化胰腺癌组织中表达明显低于中、低分化肿瘤组织,在转移组阳性表达高于非转移组(P<0.05),但在性别间差异没有统计学意义。结论PrPC在胰腺癌中表达与其发生、临床分期及转移密切相关,在其发生发展中可能起着重要作用,有望作为早期诊断及靶向治疗的分子标记。
Objective To detect the difference of PrP^C expression in pancreatic cancer and matched non-cancer tissues, and analyze the relationship between PrP^C expression in cancer tissues with clinical profile. Methods Immunohistochemisty was used to detect the expression of PrPC in pancreatic cancer and control tissues, and association of PrPC with clinicopathological data including gender, differentiation, TNM staging and metastasis, were analyzed. Results Statistical analysis showed significantly higher expression rate of PrP^C in pancreatic cancer tissues than matched non-cancer tissues, and presented a positive association of PrP^C expression with differentiation and tumor metastasis （P〈0.05）. Conclusion The expression of PrP^C was correlated with pancreatic cancer development, differentiation, TNM grade and metastasis in pancreatic cancer, indicating that it may be critical in the pathogenesis of pancreatic cancer.
出处
《现代消化及介入诊疗》
2010年第6期335-337,共3页
Modern Interventional Diagnosis and Treatment in Gastroenterology
