幽门螺杆菌相关性胃炎患者血清胃蛋白酶原检测的临床价值

Clinical value of detecting serum pepsinogen in patients with Helicobacter pylori-associated gastritis

背景幽门螺杆菌(Helicobacter pylori,Hp)可引起胃黏膜细胞的慢性炎症,并诱导胃黏膜细胞分泌胃蛋白酶原,导致血液中胃蛋白酶原含量的变化。目的探讨Hp相关性胃炎患者血清胃蛋白酶原含量变化的临床价值。方法对经胃镜和病理证实为浅表性胃炎和萎缩性胃炎的患者按照Hp阳性及阴性进行分组,采用ELISA法对其血清PGⅠ、PGⅡ含量进行检测,血清Hp-IgG抗体采用定性分析法。结果无论浅表性胃炎或萎缩性胃炎,Hp阳性组同阴性组之间比较,差异均有显著意义(P<0.05);在萎缩性胃炎组中,血清PGⅠ含量较浅表性胃炎组者中明显降低,两者相比差异有显著意义(P<0.05)。结论Hp感染慢性胃炎患者血清中PGⅠ、PGⅡ含量明显增加,PGⅠ含量的变化可以反映胃黏膜病变的程度。

Objective Helicobacter pylori （Hp） can cause chronic inflammation and a variety of metaplasia in gastric mucosal epithelial cells, and increase pepsinogen secretion, resulting in changes of blood pepsinogen content. In this study, serum pepsinogen levels were determined in Hp-associated gastritis patients in order to understand its clinical value. Methods Superficial gastritis and atrophic gastritis patients confirmed by endoscopy and pathology were divided into Hp-positive and Hp-negative groups. Concentrations of PGI, PGII in serum were detected by ELISA, and serum Hp-IgG antibodies were assayed using the qualitative analysis method. Results Whether superficial gastritis or atrophic gastritis, PGI and PG II were significantly higher in Hp-positive group than in Hp-negative group （P 0.05）, however serum PGI concentration in patients with atrophic gastritis was significantly lower than superficial gastritis patients （P 0.05）. Conclusion PGI, PGII was increased in chronic gastritis patients with Hp infection, the lower concentration of PGI may reflect the degree of gastric mucosal lesions.