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核因子-κB与幽门螺杆菌相关性萎缩性胃炎的关系研究 被引量:3

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摘要 目的探讨幽门螺杆菌(Helicobacter pylori,Hp)相关性萎缩性胃炎与NF-κB活性变化的关系。方法Hp相关性萎缩性胃炎40例及Hp根除后复查37例,浅表性胃炎(Hp阴性)30例;14C呼气实验和血清抗Hp抗体检测Hp感染;凝胶迁移率变动分析(EMSA)测NF-κB活性。结果Hp根除组NF-κB活性8016±1394.1与浅表性胃炎组7139.7±954.35比较,差异有显著性(P<0.5);Hp相关性萎缩性胃炎组的NF-κB活性9343.5±1994.3,Hp根除组比较有显著性差异(P<0.5)。结论NF-κB与Hp相关性萎缩性胃炎呈明显的正相关关系,可能参与了该病的发生过程。
出处 《现代消化及介入诊疗》 2010年第6期369-370,共2页 Modern Interventional Diagnosis and Treatment in Gastroenterology
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  • 1谢晶日,王海强,王静滨.胃灵冲剂对慢性萎缩性胃炎大鼠胃黏膜影响的实验研究[J].中国中医药科技,2006,13(5):311-312. 被引量:6
  • 2朱金宏.益气活血法治疗慢性萎缩性胃炎91例[J].实用中医药杂志,2006,22(11):685-685. 被引量:7
  • 3Ostuni R,Zanoni I,Granucci F.Deciphering the complexity of Toll-like receptor signaling[J].Cell Mol Life Sci.2010Dec;67(24):4109-4134.
  • 4Kim YJ,Jang ER,Lee JC,et al.Diarylheptanoid hirsutenoxime in-hibits toll-like receptor4-mediated NF-κB activation regulated by Akt pathway in keratinocytes[J].Am J Chin Med.2010;38(6):1207-22.
  • 5Haziri A, Juniku-Shkololli A, Gashi Z, et al. Helicobacter pylori infection and precancerous lesions of the stomach [J]. Med Arh, 2010,64(4) :248-249.
  • 6Subramaniam D, Ramalingam S, May R, et al. Gastrin- mediated interleukin-8 and cyclooxygenase-2 gene expression: differential transcriptional and posttranscriptional mechanisms [J]. Gastroenterology, 2008,134(4) : 1070-1082.
  • 7Saha A, Hammond C E, Trojanowska M, .et al. Helicobacter pylori-induced H,K-ATPase alpha-subunit gene repression is mediated by NF-kappaB p50 homodimer promoter binding [J]. Am J Physiol Gastrointest Liver Physiol, 2008,294(3): G795- 807.
  • 8Toyoda T, Tsukamoto T, Takasu S, et al. Anti-inflammatory effects of caffeic acid phenethyl ester (GAPE), a nuclear factor-kappaB inhibitor, on Helicobacter pylori-induced gastritis in Mongolian gerbils [J]. Int J Cancer,2009,125 (8) : 1786- 1795.
  • 9Mira M, Satoh M, Shimada A, et al. Metallothionein is a crucial protective factor against Helicobacter pylori-induced gastric erosive lesions in a mouse model . [J]. Am J Physiol Gastrointest Liver Physiol, 2008,294 : G877-G884.
  • 10Take S, Ishiki K, Mizuno M. Helicobacter pylori eradication therapy does not prevent gastric cancer development in all patients [J ]. Gan To Kagaku Ryoho, 2011,38 (3) : 353-357.

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