IL-2联合5-氟尿嘧啶治疗晚期肾癌50例疗效观察

The Efficacy of IL-2 Combined with 5-FU in Treatment of 50 Patients with Advanced Renal Cell Carcinoma

目的比较晚期肾癌免疫化疗和单纯免疫治疗的效果,指导临床治疗方法的选择.方法 50例晚期肾癌患者随机分为两组,每组25例,治疗组患者应用IL-2联合5氟尿嘧啶(5-Fu)治疗,所有患者均接受连续4个周期治疗;对照组单用IL-2治疗4个周期;根据WHO抗肿瘤药物客观疗效标准进行疗效评定.结果 50例患者均按实验设计完成实验,治疗组完全缓解5例,部分缓解11例,总有效率为64%;对照组完全缓解2例,部分缓解6例,总有效率为30%(6/25),两组差异具有统计学意义(P<0.05).结论小剂量IL-2联合5-Fu是治疗晚期肾癌的较好手段.

Objective To compare the efficacy between chemotherapy combined with immunotherapy and simple immunotherapy for advanced renal cell carcinoma,in order to select the better treatment.Methods 50 patients with advanced renal cell carcinoma were randomly divided into two groups,25 patients in each group.Patents in the treatment group was treated with IL-2 combined with 5-fluorouracil（5-Fu）for 4 cycles,and patients in the control group was treated with only IL-2 for 4 cycles.According to the objective standard of anticancer drug efficacy in WHO,the efficacy was evaluated.Results According to experimental design,the treatment was completed in all 50 patients.In the treatment group,5 patients got complete remission,and 11 patients got partial remission,the total effective rate was 64%（15/25）;in the control group,2 patients got complete remission,and 6 patiens got partial remission,the effective rate was 30%,there was a statistically significant difference in the total effective rate between the two groups（P0.05）.Conclusion Low dose of IL-2 combined with 5-Fu is a good means for the treatment of advanced renal cell carcinoma.