急性冠状动脉综合征患者血浆胸腺基质淋巴细胞生成素的变化

Changes and significance of plasma thymic stromal lymphopoietin levels in patients with coronary heart disease

目的:观察急性冠脉综合征(ACS)患者血浆胸腺基质淋巴细胞生成素(TSLP)水平。方法:经冠状动脉造影证实的冠心病患者98例,其中稳定型心绞痛(SAP)组40例,ACS组58例,另选取20例造影正常者作为对照组。采用ELISA法检测血浆TSLP水平,同时常规检测患者生化指标。结果:ACS组血浆TSLP浓度[(16.5±3.0)pg/ml]显著高于SAP组[(3.3±1.4)pg/ml]和对照组[(2.8±1.3)pg/ml](均P<0.01);吸烟患者TSLP浓度[(27.9±14.6)pg/ml]显著高于非吸烟患者[(12.9±4.8)pg/ml](P<0.01)。血浆TSLP浓度与血C反应蛋白及LDL正相关(分别r=0.23,P<0.05和r=0.38,P<0.01)。结论:TSLP介导的炎症反应可能与ACS发生有关。

Objective：To observe the plasma levels of thymic stromal lymphopoietin （TSLP） in patients with acute coronary syndrome （ACS）.Method：A total of 98 CAD patients conformed by coronary angiography were divided into stable angina pectoris （SAP） （n=40） and ACS group （n=58）,another 20 subjects with normal angiography results were selected as control group.Plasma TSLP was measured by ELISA.Result：Plasma concentrations of TSLP in patients with ACS group were significantly higher than those in patients with SAP and in the control group （ACS,[16.5±3.0]pg/ml; SAP,[3.3±1.4]pg/ml; control [2.8±1.3]pg/ml; P0.01）.Additionally,plasma concentrations of TSLP in smoking subjects （[27.9±14.6]pg/ml） were significantly higher than that in the non-smoker （[12.9±4.8]pg/ml,P0.01）.There were,however,no significant differences between patients with SAP and the control group.Plasma concentrations of TSLP correlated positively with C-reactive protein （r=0.23,P0.05）,and low density lipoprotein level （r=0.38,P0.01）.Conclusion：TSLP mediated inflammation maybe related to the development of ACS.