乳腺血氧功能成像系统在乳腺疾病诊断中的应用

Breast Blood-oxygen Function Imaging System in Diagnosing Breast Diseases

目的探讨乳腺血氧功能成像系统(血氧三算子)在乳腺疾病诊断中的应用价值。方法 2010年3月～9月对120例乳腺疾病进行血氧三算子、超声和乳腺钼靶检查(患者≤35岁不接受钼靶检查),3项检查至少有一项提示有手术指征,通过与术后病理对比,比较3种影像学诊断的准确性、敏感性、特异性、阳性预测值及阴性预测值。结果血氧三算子与超声、乳腺钼靶的准确率分别为93.3%(112/120)、87.5%(105/120)、82.4%(70/85);敏感性分别为93.5%(29/31)、74.2%(23/31)、61.5%(16/26);特异性分别为93.2%(83/89)、92.1%(82/89)、91.5%(54/59);阳性预测值分别为82.9%(29/35)、76.7%(23/30)、76.2%(16/21);阴性预测值为97.6%(83/85)、91.1%(82/90)、84.4%(54/64)。血氧三算子对乳腺病灶诊断的准确性、敏感性、阴性预测值优于乳腺钼靶(Z=2.212,P=0.027;Z=2.623,P=0.009;Z=2.735,P=0.006),但二者特异性和阳性预测值无统计学差异(Z=0.066,P=0.948;Z=0.395,P=0.693)。结论血氧三算子对乳腺病灶诊断具有较高的准确性、敏感性、阴性预测值,对乳腺癌的诊断有较大应用价值。

Objective To evaluate the value of blood-oxygen function imaging（tri-operators）technology in the diagnosis of early breast diseases.Methods Totally 120 patients with breast diseases were examined by tri-operators,mammography（not used in patients under 35 years）,or ultrasonography;at least one of the examinations indicated surgical treatment.The accuracy,sensitivity,specificity,and positive and negative predict values of the three examinations were compared by using postoperative pathological findings.Results The accuracy of tri-operators,ultrasonography,and mammography was 93.3%（112/120）,87.5%（105/120）,and 82.4%（70/85）respectively;sensitivity was 93.5%（29/31）,74.2%（23/31）;61.5%（16/26）;specificity was 93.2%（83/89）,92.1%（82/89）,and 91.5%（54/59）;positive predict value was 82.9%（29/35）,76.7%（23/30）,and 76.2%（16/21）;and negative predict value was 97.6%（83/85）,91.1%（82/90）,and 84.4%（54/64）.Tri-operators showed significantly superior accuracy,sensitivity and negative predict value than mammography（Z=2.212,P=0.027;Z=2.623,P=0.009;Z=2.735,P=0.0060）,but similar specificity and positive predict value（Z=0.066,P=0.948;Z=0.395,P=0.693）.Conclusions Tri-operators is superior to ultrasonography and mammography in diagnosing breast lesions due to its higher sensitivity,accuracy and negative prognostic value in screening,and it has great value in diagnosing breast cancer.