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再议肠道屏障功能分子机制的研究进展 被引量：14

Recent progress in understanding the molecular mechanisms underlying intestinal epithelial barrier function
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摘要 肠屏障功能受损与临床多种疾病的发生发展有密切的关系.近几年来国内外对益生菌的研究表明,在发挥其益生作用时,其表面蛋白的黏附结构域起着核心作用.肠上皮细胞间紧密连接蛋白的作用及地位已得到了充分的肯定,肠上皮细胞绒毛刷状缘的碱性磷酸酶(IAP),胞质内蛋白磷酸酶2A(PP2A)的保护作用及肠上皮细胞内淋巴细胞(IEL)免疫调节作用备受关注.此外,小肠干细胞(ISC)所起的作用也备受研究者的重视. Intestinal barrier dysfunction is related to the development of various clinical diseases. Recent probiotic studies have shown that the adhesive domain of surface layer proteins of lactobacillus can exert protective effects on intestinal epithelial cells. The role of tight junctions between intestinal epithelial cells in regulating intestinal epithelial barrier function has been established. Besides, intestinal alkaline phosphatase （IAP）, protein phosphatase 2A （PP2A）, and intraepithe- lial intestinal lymphocytes （IEL） are implicated in regulating intestinal epithelial barrier function. In addition, great attention has been paid to the association between intestinal stem ceils and intestinal epithelial barrier function.
作者 刘志华 秦环龙
机构地区 上海交通大学附属第六人民医院外科
出处 《世界华人消化杂志》 CAS 北大核心 2010年第33期3501-3507,共7页 World Chinese Journal of Digestology
基金 国家自然科学基金资助项目 No.81070293~~
关键词 肠屏障 益生菌 紧密连接 蛋白磷酸酶2A 上皮内淋巴细胞 碱性磷酸酶 小肠干细胞 Intestinal barrier Probiotics Tight junction Protein phosphatase 2A Intestinal intraepithelial lymphocyte Intestinal alkaline phos-phatase Intestinal stem cell
分类号 R57 [医药卫生—消化系统]
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参考文献55

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二级参考文献67

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共引文献47

同被引文献139

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二级引证文献163

世界华人消化杂志
2010年 第33期

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