摘要
目的研究胃腺癌中是否存在血管生成拟态(vasculogenic mimicry,VM)及其与MMP-2表达的关系,以及MMP-2表达的临床意义。方法收集121例胃腺癌标本及临床病例资料,利用CD34和PAS双重染色观察是否存在VM,然后对存在VM组和对照组进行MMP-2染色,分析VM与MMP-2表达的关系以及MMP-2表达与患者临床病理指标的关系。结果 121例胃腺癌中有44例(36.36%)存在VM。有VM组的MMP-2高表达的比例明显高于无VM组,两组之间的差异有统计学意义(P<0.01)。伴有淋巴结转移的胃癌组织MMP-2高表达的比例显著高于无淋巴结转移的胃癌组织(P<0.05)。结论胃腺癌中存在VM,MMP-2的高表达可能与VM形成及肿瘤淋巴结转移有关。
Purpose To study whether vasculogenic mimicry(VM) exists in gastric adenocarcinoma(GAC),its relationship with matrix metallopeptidase 2(MMP-2) and clinical significance.Methods A total of 121 cases of gastric adenocarcinoma and their clinical data were collected and dual staining of CD34 and periodic acid-Schiff(PAS) were performed to validate the existence of VM in GAC.MMP-2 expression was then detected in both groups of GAC patients with VM and without to analyze the relationship between VM and MMP-2 expression,and the correlation of MMP-2 expression with the clinicopathologic data.Results Of 121 gastric adenocarcinoma cases,VM phenomenon existed in 44(36.36%) cases.The expression of MMP-2 in patients with VM was obviously higher than the ones without VM.This difference indicated statistical significance(P0.01).The MMP-2 expression in the patients with lymph nodes metastasis was significantly higher than the ones without lymph nodes metastasis(P0.05).Conclusions VM exists in GAC.The high MMP-2 expression might be related with the formation of VM and lymph nodes metastasis.
出处
《临床与实验病理学杂志》
CAS
CSCD
北大核心
2010年第6期670-672,676,共4页
Chinese Journal of Clinical and Experimental Pathology
关键词
胃肿瘤
血管生成拟态
MMP-2
stomach neoplasms
vasculogenic mimicry
matrix metallopeptidase 2