NDRG1的作用及其在肿瘤中的研究进展

Effects of NDRG1 and Advancement of It in Tumor Research

目的综合评述N-myc下游调节基因1(NDRG1)的作用以及该基因在肿瘤中的研究进展情况。方法收集近年来有关NDRG1作用及其与肿瘤关系的文献并作综述。结果 NDRG1在机体对组织缺氧的反应、组织分化等方面发挥着重要作用,在肿瘤的形成以及侵袭和转移中的作用尤为突出。结论 NDRG1可能是肿瘤转移方面的一个候选相关基因,有望成为肿瘤的一个预后指标。

Objective To summarize the role of N-myc downstream regulated gene 1（NDRG1） and the advancement of it in tumor research.Methods Publications on line at home and abroad involving the roles of NDRG1 and the correlation between it and tumor were collected and reviewed.Results NDRG-1,has a number of important functions such as in organism responses in hypoxia,histological differentiation,and so on,especially plays a significant role in generation,metastasis,and invasion of cancer.Conclusion NDRG1 may be a candidate of metastasis relevant gene for cancer and may serve as a useful prognostic marker of carcinoma.