无症状人群高尿酸血症与高甘油三酯血症的相关性研究

Correlation between Hyperuricemia and Hypertriglyceridemia in Asymptomatic People

目的探讨无症状人群高尿酸血症与高甘油三酯血症的相关性,为临床疾病的预防和治疗提供实验基础研究。方法回顾分析2008年5月-2009年5月门诊体检中200名无临床症状高血尿酸者(A组)的血脂检查情况,并与同期200例血尿酸正常者(B组)的血脂检查情况进行比较分析。A组:男121例,女79例;年龄20～60岁,平均43岁。男性患者血尿酸>420mmol/L,女性患者>360mmol/L。B组:男115例,女85例;年龄20～60岁,平均41岁。男性患者血尿酸为99～420mmol/L,女性患者为99～360mmol/L。两组性别和年龄差异无统计学意义(P>0.05)。结果 A组甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白分别为(3.09±0.98)、(4.05±1.07)、(3.38±0.98)、(1.30±0.51)mmol/L;B组为(1.65±0.86)、(3.99±0.99)、(2.97±0.89)、(1.41±0.66)mmol/L。A组甘油三酯较B组比较,差异有统计学意义(P<0.01);总胆固醇、低密度脂蛋白、高密度脂蛋白比较,差异无统计学意义(P>0.05)。经相关性分析,A组血尿酸与甘油三酯呈正相关(r=0.69,P<0.01)。结论血尿酸代谢与甘油三酯代谢之间有一定的联系。

Objective To explore the correlation between hyperuricemia and hypertriglyceridemia in asymptomatic people to provide the basic information for clinical prevention and treatment.Methods The blood lipid （TG,TC,LDL,and HDL）levels in 200asymptomatic individuals with high uric acid（A group）and 200sex-and agematched ones with normal serum uric acid（B group）were examined and the results of the two groups were compared. Results The concentration of triacylglycerol,total cholesterol,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol were（3.09±0.98）,（4.05±1.07）,（3.38±0.98）,and（1.30±0.51）mmol/L,respectively in group A;and were（1.65±0.86）,（3.99±0.99）,（2.97±0.89）,and（1.41±0.66）mmol/L,respectively in group B.The concentration of TG in group A was obvious higher than that in group B（P0.01）.However,the differences of their total cholesterol,low-density lipoprotein cholesterol,and high-density lipoprotein cholesterol were not significant（P0.05）.The increase of TG was obvious compared with TC（P0.01）,LDL（P0.01）,and HDL（P0.01）in group A;while the comparisons in group B were not significant（P0.05）.Conclusion Uric acid metabolism correlates with triacylglycerol metabolism.