甲氨蝶呤小剂量分次给药联合米非司酮治疗早期异位妊娠的临床研究

Therapeutic Effect of Methotrexate Combined Mifepristone on Early Ectopic Pregnancy

目的探讨甲氨蝶呤(MTX)联合米非司酮治疗早期异位妊娠(EP)的临床效果。方法收集2006年2月2010年2月收治的早期未破裂型EP患者126例,随机分为MTX联合米非司酮组62例,单独应用MTX组64例,MTX治疗采用小剂量分次肌肉注射给药进行。结果 126例患者中,MTX联合米非司酮组和单独应用MTX治疗组的成功率为分别为88%和65%,两组差异有统计学意义(P<0.05)。结论 MTX小剂量分次给药联合米非司酮治疗早期未破裂型EP效果优于MTX的单独使用。

Objective To observe the therapeutic effect of methotrexate （MTX） combined with mifepristone on early ectopic pregnancy. Methods A total of 126 patients with early ectopic pregnancy diagnosed from February 2006 to Febrary 2010 were randomly divided into two groups. In 126 patients, 62 treated with MTX combined with mifepristone were in the treatment group,and 64 treated independently with MTX were in the control group. MTX was administrated at a low dose in several times. Results In 126 patients,the success ratio of the treatment was 88% in treatment group groups and 65% in the control group; the difference between the two groups was significant （P0.05）. Conclusion Low-dose MTX in separate times combined with mifepriston is effective on the early ectopic pregnancy, and the therapeutic effect of the combined administration of MTX and mifepriston is better than that of the single administration with MTX.