摘要
骨代谢或骨转换的过程是破骨细胞吸收旧骨和成骨细胞形成新骨的过程,这两个过程在时间和空间上紧密的偶联并发生在同一个再建单位体中。骨量的多少取决于同一骨再造单位中骨形成与骨吸收是否平衡。细胞因子与生长因子是骨吸收、骨形成的关键中介因子。测定血中各种细胞因子与生长因子对骨质疏松的诊断、选择治疗方案、评价疗效具有重要临床价值。笔者对细胞因子与生长因子检测的临床意义分别进行综述,并将近年研究的结果供同道分享。
The process of bone metabolism or bone turnover is the process of the old bone absorption by osteoclasts and new bone formation by osteoblasts. The two processes are coupled intimately in time and space and they occur in the same rebuilding unit. The quantity of bone depends on the balance of bone formation and bone absorption in the same bone reconstruction unit. Cytokines and growth factors are key mediators of bone absorption and bone formation. The determination of cytokines and growth factors has great clinical significance for the diagnosis, treatment options, and efficacy evaluation of osteoporosis. The author reviews the clinical significances of the detection of cytokines and growth factors respectively, and shares the results of recent research with colleagues in the field.
出处
《中国骨质疏松杂志》
CAS
CSCD
2010年第12期972-976,共5页
Chinese Journal of Osteoporosis
关键词
细胞因子
生长因子
骨代谢
骨质疏松
临床意义
Cytokine
Growth factor
Bone metabolism
Osteoporosis
Clinical significance
