雌激素受体-β在膀胱尿路上皮癌中的表达及其临床意义

Expression of estrogen receptor beta in bladder urothelial carcinoma and its clinical significance

目的 观察雌激素受体β（ER-β）在膀胱癌中的表达及其与临床病理特征的关系,探讨其临床意义.方法 采用免疫组织化学SP法检测ER-β蛋白在146例膀胱尿路上皮癌和25例正常膀胱黏膜中的表达.结果 ER-β蛋白在膀胱癌组织中阳性表达率为44.5%,在正常膀胱黏膜组织阳性表达率为20.0%,差异有统计学意义（P＜0.05）.ER-β的表达率随着膀胱癌病理分级和临床分期的升高而增高（P＜0.05）,而且与患者性别明显相关,女性阳性率显著高于男性患者（P＜0.05）.结论 ER-β在膀胱癌组织中表达有明显的性别差异,且与膀胱癌的分化和浸润性进展密切相关,提示ER-β蛋白可能在膀胱癌的发生发展中起重要作用.

Objective To investigate the expression of estrogen receptor beta （ER-β） in bladder urothelial carcinoma and to explore its clinical significance.Methods Immunohistochemical SP method was employed to detected the expression of ER-β in bladder cancer tissue （ 146 cases） and the normal controls （25 cases）.In addition,clinicopathological data of them were analyzed.Results The positive expression rate of ER-β in bladder cancer tissue was 44.5%,but low positive expression rate （20.0% ）was found in normal bladder tissue.The expression of ER-β was markedly associated with tumor pathological grade and clinical stage （ P〈0.05）.Moreover,the expression of ER-β was observed more frequently in female （59.6%） than male （37.4%） （P〈0.05 ）.Conclusion The sex difference in expression of ER-β is associated with differentiation and invasion in bladder urothelial carcinoma,it implies that ER-β might play important roles in the development and progression of bladder cancer.