虚燥更平方对雌性大鼠高血压病(更年期)性激素影响的实验研究

Experimental Study on Influence Xuzao Gengping Prescription in Sex Hormones of Female Rats Climacteric Hypertension

目的:运用虚燥更平方作用于治疗雌性大鼠高血压病(更年期),观察大鼠性激素指标治疗前后的变化,探讨虚燥更平方对性激素的影响。方法:将雌性大鼠高血压病(更年期)模型,随机分成空白组、模型组、中药组,观察3组雌激素(E2)、促卵泡刺激素(FSH)、睾酮(T)、促黄体生成素(LH)、孕酮(PRO)、催乳素(PRL)水平,并做统计分析比较。结果:虚燥更平方可使雌性大鼠高血压病(更年期)中药组治疗后血清E2水平升高,T、FSH水平降低,三者有统计学意义(P<0.05),PRO、PRL、LH无统计学意义(P>0.05)。结论:(1)虚燥更平方对改善雌性大鼠高血压病(更年期)患者性激素水平具有一定的调节作用。(2)通过比较中药组和模型组治疗前后性激素相关指标水平的变化,说明雌性大鼠高血压病(更年期)紊乱的性激素与高血压病的发生、发展关系密切。

Obctiveje：To study the clinical efficacy of Xuzao Gengping Prescription on the female climacteric hypertension rats and analyzes theirs sex hormones index before and after the treatment,observe the changes of index.To explore on influence Xuzao Gengping prescription in sex hormones.Methods：the female climacteric hypertension rat model,Randomly divided into blank group,Chinese traditional medicine group,the model group,observe three group,estrogen（E2）,follicle-stimulating hormone（FSH）,T（testosterone）,corpus luteum（LH）,progesterone（PRO）,prolactin（PRL）level,and statistical analysis is made.Results：Xuzao Gengping Prescription can make the female rat climacteric hypertension of Chinese traditional medicine group after the treatment,E2 raiseded levels,T,FSH reduced levels,a statistically significant（P〈0.05）,PRO,PRL,LH was not statistically significant（P〉0.05）.Conclusions：（1）Xuzao Gengping Prescription has certainly regulate function to improve the levels of sex hormones of female climacteric hypertension.（2）Through the Chinese traditional medicine group and the model group related indexes and levels of sex hormones,female climacteric hypertension rats with the occurrence and development of hypertension relation,disorder sex hormone index may participate the patho-physiological course of menopausal hypertension in female.