期刊文献+

帕金森病中晚期的临床表现与治疗 被引量:4

Clinical Manifestations and Treatment of Parkinson's Disease in the Middle and Late Period
下载PDF
导出
摘要 帕金森病是一种中枢神经系统变性疾病,病因主要是位于中脑部位的"黑质"中细胞发生病理性改变,多巴胺合成减少,抑制乙酰胆碱的功能降低,乙酰胆碱的兴奋作用相对增强,两者之间的平衡失调所致。近年来,对帕金森病的发病机制研究有了很大的突破,治疗方式也由单一治疗到联合干预的综合治疗,治疗方案逐渐个体化。本文对近年学者对中晚期帕金森病患者的临床表现及治疗方法作一综述。 Parkinson's disease is a degenerative disease of the central nervous system, mainly caused by the "black mass" located in the midbrain area occurred pathologic changes in cells and reduction of dopamine synthesis, Reduces the inhibitory function to acetylcholine, the excitatory effect of acetylcholine is relatively enhanced.The imbalance between the two leading to the disease. So the clinical manifestations and treatment of Parkinson's disease in the Middle and late period in recent years are reviewed in this paper.
出处 《中国现代医生》 2011年第6期11-13,共3页 China Modern Doctor
关键词 帕金森病 临床表现 治疗 黑质细胞 Parkinson's disease Clinical manifestations Treatment Black mass cell
  • 相关文献

参考文献11

  • 1Inzelberg R, Nisipeanu P, Schechtman E. Practice parameter :initiation of treatment for Parkinson's disease:an evidence-based review[J]. Neurology ,2002 ,59 (8) :1292-1292.
  • 2刘爽,刘明亮,孙雪莲,夏彩秋,徐彦华.帕金森氏病临床治疗研究[J].中国现代药物应用,2010,4(4):41-41. 被引量:6
  • 3Olanow CW, Watts RL, Koller WC. An algorithm (decision tree) for the management of Parkinson disease(2001): treatment guidelines [J]. Neurology ,2001,56(suppl 5): S1-88.
  • 4Bonneville F, Welter ML, Elie C, et al. Parkinson disease, brain volumes, and subthalamic nucleus stimulation[J]. Neurology, 2005 , 64(9):1598-1604.
  • 5汪锡金,张煜,陈生弟.帕金森病发病机制与治疗研究十年进展[J].中国现代神经疾病杂志,2010,10(1):36-42. 被引量:89
  • 6Prasad KN, Kumar B, Yan XD, et al. Alpha-Tocopheryl succinate, the most effective form of Vitamin E for adjuvant cancer treatment: A Review[J]. J Am Coll Nutr,2003,22(2):108-117.
  • 7Stocchi F. The levodopa wearing-off phenomenon in Parkinson's disease: pharmacokinetic considerations[J]. Expert Opin Pharmacother, 2006, 7(10):1399-1407.
  • 8王俊梅.帕金森氏病药物治疗的探讨[J].实用心脑肺血管病杂志,2009,17(12):1117-1118. 被引量:10
  • 9刘振国.浅谈帕金森病治疗的并发症——异动症[J].中华老年医学杂志,2006,25(12):933-934. 被引量:10
  • 10陈生弟,周海燕.肌张力障碍的研究现状和未来展望[J].中国神经精神疾病杂志,2009,35(6):384-384. 被引量:3

二级参考文献89

  • 1Tarsy D, Simon DK. Dystopia[ J]. N Engl J Med, 2006, 355 (8) : 818 -829.
  • 2Geyer HL, Bressman SB. The diagnosis of dystonia [ J ]. Lancet Neurol, 2006, 5(9): 780-790.
  • 3Kartha N. Dystonia[J]. Clin Geriatr Med, 2006, 22(4) : 899 -914.
  • 4Quartarone A, Rizzo V, Morgante F. Clinical features of dystonia:a pathophysiological revisitation[ J]. Curr Opin Neurol, 2008, 21 (4) :484 -490.
  • 5Wichmann T. Commentary: Dopaminergic dysfunction in DYT 1 dystonia [ J ]. Exp Neurol, 2008, 212 ( 2 ) :242 - 246.
  • 6Albanese A, Barnes MP, Bhatia KP, et al. A systematic review on the diagnosis and treatment of primary ( idiopathic ) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force[J]. Eur J Neurol, 2006, 13(5) :433 -444.
  • 7Jankovic J. Treatment of dystonia[ J]. Lancet Neurol, 2006, 5 (10) :864 -872.
  • 8Papapetropoulos S, Singer C. Botulinum toxin in movement disorders[J]. Semin Neurol, 2007, 27(2) :183 -194.
  • 9Sheean G. Cervical dystonia: unresolved issues and future challenges[ J ]. Neurol Clin, 2008, 26 ( Suppl 1 ) :66 - 76.
  • 10Swope D, Barbano R. Treatment recommendations and practical applications of botulinum toxin treatment of cervical dystonia [ J ]. Neurol Clin, 2008, 26 ( Suppl 1 ) :54 - 65.

共引文献112

同被引文献27

引证文献4

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部