中药骨疏灵和运动联合干预去势大鼠骨质疏松形成的研究

Combined Intervention of the Traditional Chinese Medicine Gushuling and Exercise on the Formation of Osteoporosis in Ovariectomed Rats

目的:探讨中药骨疏灵和运动联合干预去势大鼠骨质疏松形成的效果。方法:手术切除大鼠双侧卵巢造成绝经后骨质疏松模型,按体重随机将大鼠分为假手术组(SHAM组)、模型组(OVX组)、雌激素对照组(DES组)、中剂量中药加低强度运动组(LEX+MH)、高剂量中药加低强度运动组(LEX+HH)、中剂量中药加中强度运动组(MEX+MH)、高剂量中药加中强度运动组(MEX+HH)。观察各组大鼠骨生物力学指标的变化。结果:中药加运动方案各组除LEX+MH组外,椎体结构力学参数与SHAM组和DES组差异不明显(P>0.05),MEX+HH组各指标相对于其它治疗组更接近于SHAM组。各治疗组股骨生物力学指标无明显差异(P>0.05)。结论:中药骨疏灵和运动联合方案可延缓去势大鼠骨生物力学的降低,防治骨质疏松,MEX+HH组效果最佳。

Objective： The purpose of the study is to observe the combined effect of the traditional Chinese medicine Gushuling and exercise on the formation of osteoporosis in ovariectomed rats.Methods： 70 SD female rats are weighed and grouped into 7 groups： the sham group,the OVX group,the DES group,the LEX ＋MH group,the LEX＋HH group,the MEX＋MH group and the MEX＋HH group.Results： Except the LEX＋HH group,there is no marked difference in the biomechanical parameter of the vertebal body with the sham group and DES group（P0.05）. The biomechanics of the vertebral body of the MEX＋HH group is closet to the Sham group compared with other treatment groups,with no marked difference in teh biomechanical indexes among the treatment groups（P0.05）.Conclusion： The compound treatment scheme could slow down the formation of osteoporosis.The best combination effect is seen in the MEX＋HH group.