中国汉族人群β2肾上腺素能受体基因多态性与原发性高血压关联的Meta分析

Relationship between genetic polymorphisms of β2-adrenergic receptor gene and essential hypertension risk among the Han Chinese population： a Meta analysis

目的 评价β2肾上腺素能受体（ADRB2）基因A46G、C79G位点多态性与中国汉族人群原发性高血压（EH）发病的关系. 方法 计算机检索Pubmed、Embase、中国期刊全文数据库、万方数据库、重庆维普数据库,检索时间范围包括2010年5月之前的所有文献,分别检索到研究我国汉族人群ADRB2基因A46G、C79G位点多态性改变与EH相关性的文献15篇和10篇.按纳入、排除标准选取ADRB2基因A46G、C79G位点多态性与EH的病例-对照研究,采用RevMan 4.2进行定量分析相关性. 结果 分别纳入研究A46G位点文献8篇（涉及1078例EH患者和788名正常血压者）、C79G位点文献6篇（涉及1367例病例及1006名正常对照）.Meta分析结果表明,中国汉族人群EH易感性与A46G位点多态性相关：基因型GG与（AA＋AG）相比,固定效应模型,OR=1.35,95%CI=1.04～1.74,P=0.02;基因型GG与AA相比,固定效应模型,OR=1.41,95%CI=1.06～1.89,P=0.02.C79G位点多态性与中国汉族人群EH相关性无统计学意义：等位基因G与C相比,随机效应模型,OR=0.88,95%CI=0.55～1.39,P=0.57. 结论 ADRB2基因A46G位点多态性与我国汉族人群EH的易感性相关,C79G 位点多态性与中国汉族人群EH无关.

Objective To evaluate the relationship between A46G and C79G polymorphisms in the β2-adrenergic receptor （ADRB2） gene and the incidence of essential hypertension （EH） among the Han Chinese population. Methods We conducted a computer retrieval of PUBMED,EMBASE,CNKI,Wanfang and VIP databases prior to May 2010.Articles investigating the relationship of EH and ADRB2 gene polymorphism of Han group were found through literature search,including 15 articles on A46G and 10 articles on C79G.According to the including and excluding criteria,a Meta-anatysis was conducted in EH and ADRB2 gene polymorphism of A46G and C79G.The association was examined by RevMan4.2 software through quantitative analysis. Results Eight articles on A46G polymorphism （including 1078 EH cases and 788 control subjects） and six articles on C79G polymorphism （including 1367 EH cases and 1006 control subjects） were included in the current study.Meta-analysis showed that there was a significant association between A46G polymorphism and EH：genotype GG/（AA＋AG）（fixed-effected model,OR=1.35,95% CI=1.04-1.74,P=0.02）,genotype GG/AA （fixed-effected model,OR=1.41,95% CI=1.06-1.89,P=0.02）.No significant association was found between C79G polymorphism and EH of Han group in China：G/C allele comparison （random-effected model,OR=0.88,95% CI =0.55-1.39,P =0.57）. Conclusion Significant association was found between A46G polymorphism of ADRB2 gene and EH,whereas no association could be found between C79G polymorphism and EH among Han Chinese population.