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多重基因表达分析系统在氨基糖苷类多重耐药基因检测中的应用 被引量：9

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摘要 氨基糖苷类抗生素耐药趋势逐年增强，氨基糖苷类耐药基因的研究成为近年来研究的热点问题。与细菌耐药最为密切的是氨基糖苷类修饰酶（aminoglycoside modifying enzymes，AMEs）基因和16S rRNA甲基化酶（16S rRNA methylase）基因，国内最常见的氨基糖苷类抗生素相关的耐药基因有：5种AMEs基因aac（3）-Ⅱ、aac（6’）-Ⅰb、aac（6’）-Ⅱ、ant（3＂）-Ⅰ、
作者 胡秀梅 徐邦牢 杨银梅 周小棉 杨梦婕 王淼 马学军
机构地区 广州医学院附属广州市第一人民医院检验科 暨南大学生殖免疫研究所 中国疾病预防控制中心病毒病预防控制所病毒基因工程国家重点实验室
出处 《中华预防医学杂志》 CAS CSCD 北大核心 2011年第2期181-183,共3页 Chinese Journal of Preventive Medicine
关键词 氨基糖苷类抗生素 基因检测 基因表达分析 多重耐药 rRNA甲基化酶 氨基糖苷类修饰酶 应用 系统
分类号 R440 [医药卫生—诊断学]
  • 相关文献

参考文献11

  • 1Davies J,Wright GD.Bacterial resistance to aminoglycoside antibiotics.Trends Microbiol,1997.5:234-240.
  • 2吴琼,倪语星.一种新的氨基糖苷类耐药决定因子:质粒介导的16S rRNA甲基化酶[J].微生物与感染,2009,4(1):45-48. 被引量：16
  • 3糜祖煌,陆亚华.氨基糖苷类修饰酶及其基因检测[J].现代实用医学,2004,16(1):13-14. 被引量：143
  • 4Tabone T,Mather DE,Hayden MJ.Temperature switch PCR (TSP):Robust assay design for reliable amplification and genotyping of SNPs.BMC Genomics,2009,10:580-593.
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  • 7Qin M,Wang DY,Huang F,et al.Dection of pandemic influenza A H1N1 virus by multiplex reverse transcription-PCR with a GeXP analyzer.J Virol Methods,2010,168 (1/2):255-258.
  • 8Yokoyama K,Doi Y,Yamane K,et al.Acquisition of 16S rRNA methylase gene in Pseudomonas aeruginosa.Lancet,2003,362:1888-1893.
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二级参考文献22

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  • 9Yan JJ, Wu JJ, Ko WC, et al. Plasmid-mediated 16S rRNA methylases conferring high-level aminoglycoside resistance in Escherichia coil and Klebsiella pneumoniae isolates from two Taiwan Residents hospitals [ J ]. J Antimicrob Chemother, 2004,54 ( 6 ) : 1007-1012
  • 10Lee H, Yong D, Yum JH, Roh KH,et al. Dissemination of 16S rRNA methylase-mediated highly amikacinresistant isolales of Klebsiella pneumoniae and Acinetobacter baumannii in Korea [ J ]. Diagn Microbiol Infect Dis ,2006,56( 3 ) :305-312

共引文献156

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引证文献9

二级引证文献56

中华预防医学杂志
2011年 第2期

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