依那普利联合苯磺酸氨氯地平治疗原发性高血压的疗效观察

The clinical observation on the Enalapril combined with Amlodipine Besylate in treatment of essential hypertension

目的:探讨依那普利联合苯磺酸氨氯地平在原发性高血压治疗中的疗效。方法:选取2008年1月～2010年10月的98例原发性高血压患者为研究对象,将其随机分为对照组(苯磺酸氨氯地平组)49例和观察组(依那普利联合苯磺酸氨氯地平组)49例,后将两组患者的治疗总有效率、不良反应发生率及治疗前后的血压水平、心肌肥厚情况进行统计及比较。结果:经研究及比较发现,观察组的治疗总有效率高于对照组,心肌肥厚改善效果优于对照组,均有显著性差异(均P<0.05),而两组不良反应发生率比较,无显著性差异(P>0.05)。结论:依那普利联合苯磺酸氨氯地平在原发性高血压的疗效较好,值得临床推广应用。

Objective： To study the effects of Enalapril combined with Amlodipine Besylate in treatment of essential hypertension.Methods： 98 patients with essential hypertension from January 2008 to October 2010 were selected as research object,and all the patients were randomly divided into control group（Amlodipine Besylate group）49 cases and observation group（Enalapril combined with Amlodipine Besylate group）49 cases,then the total effective rate,incidences of adverse reactions and the blood pressure,situation of cardiac hypertrophy before and after the treatment were studied and compared.Results： The total effective rate of observation group was higher than that of control group,the improvement of cardiac hypertrophy was better than that control group,there were significant differences（all P0.05）,but the incidences of adverse reactions of the two groups were compared,there were no significant differences（P0.05）.Conclusion： The effect of Enalapril combined with Amlodipine Besylate in essential hypertension is better,and it deserves further clinical applications.