2型糖尿病胰岛素抵抗与多项血清因子水平的相关性分析

Study on the correlation between insulin resistance and various serum factors in type 2 diabetes mellitus

目的：探讨2型糖尿病胰岛素抵抗与血清IL-6、TNF-α、hs-CRP及FFA水平的相关性。方法：选取2008年12月~2010年9月在我院进行治疗的50例2型糖尿病患者为观察组,同时选取50名健康体检人员为对照组,对两组人员的血清IL-6、TNF-α、hs-CRP及FFA水平与胰岛素抵抗指数（HOMA-IR）进行统计及比较。结果：经研究比较发现,观察组的血清IL-6、TNF-α、hs-CRP及FFA水平与HOMA-IR均高于对照组,两组结果数据比较差异有统计学意义（P〈0.05或P〈0.01）。结论：2型糖尿病胰岛素抵抗与血清IL-6、TNF-α、hs-CRP及FFA水平有极大的相关性,值得进一步研究及探讨。

Objective：To study the correlation between insulin resistance and serum IL-6,TNF-α,hs-CRPand FFA in type 2 diabetes mellitus.Methods： 50 patients with type 2 diabetes mellitus in our hospital from December 2008 to September 2010 were selected as observation group,and 50 healthy people were selected as control group at the same time,then the serum IL-6,NF-α,s-CRP,FA and HOMA-IR of the two groups were analyzed and compared.Results： The serum IL-6,NF-α,s-CRP,FA and HOMA-IR of the observation group were higher than those of control group,there were significant differences in two groups（P0.05 or P0.01）.Conclusion： There are correlations between insulin resistance and serum IL-6,TNF-αk,hs-CRPand FFA,and it is worthy to further study.