摘要
目的:观察通腑与泻肺法及其配伍应用对ALI/ARDS大鼠肺肠组织sIgA含量的影响。方法:将100只健康wistar大鼠随机分为5组:对照组、模型组、泻肺组、通腑组和通腑泻肺组,采用尾静脉注射油酸加内毒素的方法造成大鼠ALI/ARDS模型,检测各组大鼠肺肠组织sIgA含量。结果:通腑法、泻肺法和通腑泻肺法均可有效降低肺肠组织sIgA含量,且通腑与泻肺法配伍应用效果明显优于二法单独应用。结论:在调节ALI/ARDS大鼠黏膜免疫功能方面,肺肠同治具有明显优势。
Objective：To observe the effect of Tongfu-therapy,Xiefei-therapy and Tongfu Xiefei-therapy on sIgA content in lung and large intestine in ALI/ARDS rats.Methods：We divided the health Wistar rats into 5 groups,Control group,model group,lung treatment group,large intestine treatment group and lung-large intestine treatment group.We made the ALI/ARDS-rat model by Intravenous injecting oleic acid and endotoxin in caudal vein,and observed sIgA content in lung and large intestine organs.Results：All of Tongfu-therapy,Xiefei-therapy and Tongfu Xiefei-therapy could effectively reduce the sIgA content in lung and large intestine,and the method of combining Tongfu-therapy with Xiefei-therapy was superior to the single method.Conculsion：Lung-large intestine treatment is great advantage in regulating immunologic function of mucous membrane in ALI/ARDS rats.
出处
《中国医药导报》
CAS
2011年第6期20-21,64,共3页
China Medical Herald
基金
国家重点基础研究发展计划课题(2009CB522702)
国家自然科学基金面上项目(30701115)
天津市应用基础及前沿技术研究计划项目(08JCYBJC11000)
