三氧化二砷治疗老年急性髓系白血病临床观察

Clinical observation of Arsenic Trioxide in treatment of senile acute myeloid leukemia

目的:探讨三氧化二砷治疗老年急性髓系白血病的疗效。方法:选取我科2005年1月～2010年1月住院的急性髓系白血病患者(非M3型)22例(治疗组),应用三氧化二砷治疗2个疗程,并与同期20例(对照组)应用DA方案进行联合化疗的患者作比较。比较两组的缓解率、不良反应发生情况。结果:治疗组完全缓解率为31.82%,有效率为59.09%;对照组完全缓解率为30.00%,有效率为65.00%,两组疗效差异无统计学意义(P>0.05)。但治疗组的不良反应发生率明显低于对照组(P<0.05)。结论:三氧化二砷治疗老年急性白血病疗效可靠、不良反应少,患者耐受性好。

Objective：To explore clinical effect of Arsenic Trioxide on senile acute myeloid leukemia.Methods：22 senile patients with acute myeloid leukemia were allocated in treatment group,they accepted the treatment of Arsenic Trioxide.Another 20 senile patients were allocated in control group,they accepted DA combined chemotherapy.Complete remission rate and adverse reactions of two groups were compared.Results：Complete remission rate of treatment group was 31.82%,effective rate was 59.09%;those of control group were 30.00% and 65.00% respectively,there were no difference between them（P0.05）.But there was significant difference between adverse reactions（P0.05）.Conclusion：Therapeutic effect of Arsenic trioxide for senile acute leukemia is good and adverse reaction is little,patients can better tolerated.