摘要
目的:探讨苯磺酸氨氯地平治疗高血压的临床疗效及安全性。方法:将社区门诊确诊的100例高血压患者随机分为对照组与观察组,每组50例,对照组给予硝苯地平治疗;观察组给予苯磺酸氨氯地平治疗,8周为1个疗程,两组均治疗1个疗程后,观察临床疗效,比较两组治疗前后的心率和血压变化情况及不良反应发生率。结果:观察组治疗后的收缩压和舒张压均明显低于对照组(P<0.05),两组治疗前后心率变化无统计学意义(P>0.05);观察组的显效率为74.0%,总有效率为96.0%,均高于对照组的62.0%和86.0%(P<0.05);两组不良反应比较无统计学意义(P>0.05)。结论:苯磺酸氨氯地平是一种安全有效的治疗高血压药物。
Objective:To investigate the efficacy and safety about the treatment of hypertension with amlodipine besylate.Methods:100 patients with hypertension were randomly divided into control group and observation group,n=50,the control group was given nifedipine;the observation group received the treatment with amlodipine besylate.One course lasted 8 weeks.After one course,the two groups were compared on the heart rate,blood pressure and adverse reaction rate.Results:After treatment,the systolic and diastolic blood pressure were significantly lower than the control group,the heart rate changes before and after treatment in both groups was not significant;obvious effective rate and effective rate of the observation group was 74.0% and 96.0%,which was higher than 62.0% and 86.0% of the control group;the two groups showed no statistically significant in adverse effects.Conclusion:Amlodipine besylate is a safe and effective treatment for hypertension.
出处
《中国医药导报》
CAS
2011年第6期49-50,共2页
China Medical Herald
关键词
苯磺酸氨氯地平
硝苯地平
高血压
临床观察
Amlodipine besylate
Nifedipine
Hypertension
Clinical observation