摘要
某些疾病产生的根源在于多种因素引起基因表达的改变,单靶点药物在治疗这些多因素引起的复杂性疾病时疗效欠佳或毒性较大,而多靶点药物可以同时调节人类疾病网络中的多个环节,对各靶点产生协同效应,故对癌症、神经系统疾病、糖尿病、高血压及艾滋病等有较好的治疗效果。综述多靶点药物的分类、作用特点及其分子设计和筛选策略的研究进展。
The origin of the some diseases is ascribed to the altering of gene expression caused by multiple factors.When used in these diseases,the single-target drugs usually exert unsatisfying therapeutic effects or have severe toxicity,while the multi-target drugs give satisfactory therapeutic effects due to their acting multiple nodes of the human disease network and simultaneously produce synergistic effect of the targets.Therefore the multi-target drugs may be used to treat complex disease systems such as tumor,nervous system,diabetes,high blood pressure and AIDS.This review summarized the classification,characteristics,design strategies and molecular models of the multi-target drugs.
出处
《药学进展》
CAS
2011年第2期49-57,共9页
Progress in Pharmaceutical Sciences
基金
川北医学院苗圃基金[No.苗圃(10)医-12]
