妊娠高血压综合征孕妇血浆尾加压素Ⅱ与血清C反应蛋白检测水平的临床意义

Clinical Implications of Plasma Urotensin Ⅱ and Serum C-reactive Protein Levels in Patients with Pregnancy-induced Hypertension Syndrome

目的探讨妊娠高血压综合征(pregnancy-induced hypertension syndrome,PI H)孕妇血浆尾加压素Ⅱ(urotensin Ⅱ,UⅡ)与血清C反应蛋白(C-reactive protein,CRP)检测水平的临床意义。方法采用酶联免疫吸附法(enzyme-linked immunoassay,ELISA)检测30例妊娠高血压综合征孕妇(PI H组)、30例正常孕妇(对照组A)和30例非妊娠健康妇女(对照组B)血浆尾加压素与血清C反应蛋白的水平变化。结果 PIH组血浆UⅡ与血清CRP检测水平均明显高于正常孕妇和非妊娠健康妇女,差异有统计学意义(P<0.01)。直线相关分析表明,PIH组孕妇的血浆UⅡ与血清CRP具有显著相关性(r=0.893,P<0.01)。结论测定PIH血浆UⅡ与血清CRP,能够及时了解血管内皮细胞损伤和炎症反应程度,利于PIH预防及早期治疗。

Objective To explore the clinical implications of plasma urotensin Ⅱ （UⅡ） and serum C-reactive protein （CRP） levels in patients with pregnancy-induced hypertension syndrome （PIH）. Methods The levels of plasma UⅡ and CRP in 30 PIH patients, 30 normal pregnant women and 30 non-pregnant healthy women were detected by enzyme-linked immunoassay （ELISA）. Results The levels of plasma UⅡ and serum CRP in PIH patients were significantly higher than those in the other two groups （P0.01）. There was significant correlation between UⅡ and CRP levels in PIH patients （r=0.893, P0.01）.Conclusion Detection of plasma UⅡ and serum CRP in PIH patients avails for the exploration of the vascular endothelial cell damage and inflammation reaction degree, and prevention and early treatment of PIH.