突发性耳聋患者HMGB1和VE-cadherin含量变化的意义

Determination of Serum HMGB1 and Vascular Endothelial Cadherin in Patients with Idiopathic Sudden Sensorineural Hearing Loss and Its Clinical Significance

目的探讨突发性耳聋患者血清高迁移率蛋白-1(HMGB1)和血管内皮细胞钙黏蛋白(VE-cadherin)的含量变化,及其在突发性耳聋发生过程中的作用和意义。方法采用酶联免疫(ELISA)法检测血清HMGB1和VE-cadherin含量;检测102例突发性耳聋患者、35例其他疾病对照组和30例正常健康对照组的血清HMGB1和VE-cadherin含量,并比较治疗前后血清HMGB1和VE-cadherin的测定结果。结果突发性耳聋患者治疗前血清HMGB1和VE-cadherin含量较两对照组显著升高(P<0.01);治疗后恢复组患者HMGB1和VE-cadherin含量明显降低。突发性耳聋患者血清HMGB1和VE-cadherin含量之间呈正相关(r=0.68,P<0.01)。结论血清HMGB1和VE-cadherin水平的变化与突发性耳聋病情严重程度密切相关。

Objective To study the role and clinical significance of serum high mobility group box-I （ HMGB1 ） and vascular endothelial cadherin（VE-cadherin） in idiopathic sudden senonineural hearing loss. Methods The levels HMGB1 and VE=cadherin were determined by ELISA method in 102 patients with idiopathic sudden sensorineural hearing loss（ group A） ,35 patients with other neurologie diseases （group B ,20 cases with sciatica, 16 cases with trigeminal neuralgia） and 30 healthy people （group C, as normal control）. Results The serum levels HMGB1 and VE-cadherin in group A were markedly higher than those of other two groups（ P 〈 0.01 ） ;and the levels of HMGB1 and VE-cadherin in group A decreased obviously as compared to the level be- fore the treatment（P 〈0.0! ）. There was a correlation between HMGB1 and VE-cadherin in patients with idiopathic sudden sen- sorineural hearing loss （r = 0.68, P 〈 0.01 ）. Conclusion The serum levels of HMGB1 and VE-cadherin have instructive signifi- cance in the treatment and prognosis estimating of patients with idiopathic sudden sensorineural hearing loss.