血清Tg变化在甲癌术后^(131)I首次清甲中的价值

Clinical Value of Determination of Changes of Serum Thyroglobulin (Tg) Levels in Patients Receiving First ^(131)I Ablation Therapy After Thyroidectomy for Cancer

目的:评价在分化型甲状腺癌患者术后^(131)I首次清甲中血清Tg变化对于清甲效果的预测价值。方法:38例接受甲状腺全切或次全切手术后行放射性^(131)I首次清甲治疗的分化型甲状腺癌患者,应用放射免疫分析所有患者服用^(131)I前的血清Tg(TgD0),以及服用^(131)I后第5d的血清Tg(TgD5),观察清甲成功与失败两组间TgD0、TgD5以及TgD5/TgD0的差异。结果:服^(131)I前的血清Tg值(TgD0)在两组之间没有统计学差异,而清甲成功组服^(131)I后第5d血清Tg值(TgD5)、血清Tg前后变化率(TgD5/TgD0)明显的高于清甲失败组。结论:服用^(131)I后第5d的血清Tg(TgD5)、血清Tg前后变化率(TgD5/TgD0)对于分化型甲状腺癌患者术后^(131)I首次清甲是否成功有一定的预测价值。

Objective To evaluate the predictive value of change of serum thyroglobulin levels for the result of postoperative 131I ablation therapy in patients with differentiated thyroid cancer. Mothods Serum thyroglobulin （Tg） levels were measured with RIA in 38 patients with differentiated thyroid cancer receive first 1311 ablation therapy after total or subtotal thyroideetomy both before 131I administration （TgD0） and 5 days after 131I administration （TgD5）. Flosults Clinical result one year after the 131I ablation therapy was considered as saeeessfu/ in 25 patients and failed in 13 patients. There was no statistic difference between the TgD0 levels of the two groups, but both TgD5 and TgD5/TgD0 levels in successful ablation group were significantly higher than those in the failed group. Oonelusion TgD5 and TgD5/TgD0 levels have predictive value for the result of first 1311 ablation therapy in patients with differentiated thyroid cancer.