浓缩铀UO_2F_2在体内滞留诱发精子畸形效应

Effect of UO_2F_2 on Retention and Sperm Abnormality In Mice

本文采用静脉和睾丸注射两种染毒方式,研究了浓缩铀UO_2F_2在小鼠肾、肝、骨骼及睾丸的滞留,以及在睾丸中的廓清过程。发现静脉注入后,铀主要蓄积在肾脏和骨骼;UO_2F_2在睾丸内的滞留可诱发精子畸形效应,表现在皋丸注入微量UO_2F_2后第13和36天,小鼠精子畸形率明显增升;至第60天,精子畸形率即恢复至接近对照组的水平,但高剂量组的畸形率仍高于对照组,说明精原细胞和睾丸精子或精细胞对UO_2F_2是敏感的。

This paper describes the retention of uranium in mice following intravenous in- jection,testicular clearance and sperm abnormality caused by UO_2F_2 following testi- cular injection.The renal concentration of uranium is the highest of all tissues assayed,the skeleton one the second.The testicular clearance of uranium is signi- ficant.UO_2F_2 in mouse testes can markedly induce sperm abnormality 13 and 36 days after administration and the sperm abnormality rate increases with the administered dose.The rate goes down 60 days after administration.