盐酸纳洛酮鼻腔喷雾剂的药效学研究

Pharmacodynamic study of nasal spray of naloxone hydrochloride

目的:评价盐酸纳洛酮鼻腔喷雾剂的药效。方法:以新西兰大耳白兔为动物模型,通过给予中毒剂量的盐酸二氢埃托啡建立阿片类药物中毒模型,考察高、中、低三个浓度盐酸纳洛酮鼻腔喷雾剂的药效,并与肌内注射及静脉注射盐酸纳洛酮注射液的救治效果进行比较。结果:盐酸纳洛酮鼻腔喷雾剂治疗效果与肌注相当。结论:盐酸纳洛酮鼻腔喷雾剂起效迅速,救治效果显著,使用方便,特别适合危重症病人的自救与互救。

Objective：To evaluate pharmacodynamics of nasal spray of naloxone hydrochloride.Methods：The opioids poisoning model was established by injection of toxic dose of dihydroetorphine hydrochloride in rabbit to investigate the pharmacodynamics of nasal spray of naloxone hydrochloride in different concentrations,and the pharmacodynamics of naloxone hydrochloride was evaluated after intranasal,intramuscular and intravenous administration.Results：Treatment effectiveness of naloxone hydrochloride after intranasal administration is equivalent with that of intramuscular administration.Conclusion：Nasal spray of naloxone hydrochloride can be absorbed fast and have an evident effect,and therefore it is suitable for self-aid and buddy aid of patients.