期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Vimentin在肾癌组织中的表达及临床意义 被引量：3

Expression of Vimentin in renal cell carcinoma and its clinical significance
下载PDF
导出
摘要 目的探讨波形蛋白(Vimentin)在肾癌组织中的表达与病理分期、分级及预后的相关性。方法采用免疫组织化学方法检测38例肾癌组织中Vimentin的表达。结果 Vimentin表达阳性率,在肾癌组织中为78.9%,在癌旁组织中为5%,两组比较,差异有统计学意义(P<0.001);Vimentin在肾癌组织中的表达,是预后不良的指标,随病理分期、分级的增高,有升高趋势,差异有统计学意义(P<0.05)。结论 Vimentin在肾癌组织中的高表达有助于明确诊断,可作为肾癌分期、分级及预后判断的指标,对肾癌术后辅助治疗,可能有一定的参考价值。 Objective To investigate vimentin expression in renal cell carcinoma（RCC） and its association with pathological stage,grade and prognosis.Methods 38 cases of renal cell carcinoma were analysed for vimentin expression by immunohistochemical method.Results The positive rate of vimentin expression in RCC was 78.9%,while it was 5% in normal renal tissue,There was the significant difference between RCC and normal tissue（P0.001）;Up-regulation of Vimentin expression in RCC associated with poor prognosis,progressive clinical stage（P0.05） and high pathological grade（P0.05）.Conclusion Overexpression of vimentin may help to diagnose and may be as an indicator to stage,grade and predict outcome in RCC.It will be available for postoperative adjuvant treatment in RCC.
作者 孙守田 汪岩 许宁 金美善 崔延义 张小军
机构地区 吉林大学第一医院泌尿外科 吉林大学第一医院病理科
出处 《中国实验诊断学》 北大核心 2011年第2期251-253,共3页 Chinese Journal of Laboratory Diagnosis
关键词 波形蛋白 肾脏 肾癌 免疫组化 vimentin kidney renal cell carcinoma immunohistochemical method
分类号 R737.11 [医药卫生—肿瘤]
  • 相关文献

参考文献12

  • 1Wang N,Stamenlvic D.Mechanics of vimentin intermediate filaments[J].J Muscle Res Cell Motil,2002,23:535.
  • 2Stenzl A,deKernion JB.The natural history of renal cell carcinoma[J].Semin Urol,1989,7:144.
  • 3Savagner P.Leaving the neighborhood:molecular mechanisms involved during epithelial-mesenchymal transition[J].BioEssays,2001,23(10):912.
  • 4Osborn M,Weber K.Intermediate filaments:cell-type specific markers in the differentiation and pathology[J].Cell,1982,31:303.
  • 5Rodríguez-Pinilla SM,Sarrio D,Honrabo E,et al.Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas[J].J Clin Pathol,2007,60 (9):1006.
  • 6Kim KR,Choi HN,Lee HJ,et al.A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma[J].Oncol Rep,2007,18(4):825.
  • 7Singh S,Sadacharan S,Su S,et al.Overexpression of Vimentin:Role in the invasive phenotype in an androgen independent model of prostate cancer[J].Cancer Res,2003,63(9):2306.
  • 8Perlson E,Michaelevski I,Kowalsman N,et al.Vimentin binding to phosphorylated Erk sterically hinders enzymatic dephosphorylation of the kinase[J].J Mol Biol,2006,364 (5):938.
  • 9吴志新,何辉,宋天保.波形蛋白在肾细胞癌组织中的表达及其临床意义[J].陕西医学杂志,2006,35(11):1425-1427. 被引量：4
  • 10Skinnider BF,Folpe AL,Hennigar RA,et al.Distribution of cytokeratins and vimentin in adult renal neoplasms and normal renal tissue potential utility of a cytokeratin antibody panel in the differential diagnosis of renal tumors[J].Am J Surg pathol,2005,29:747.

二级参考文献11

共引文献5

同被引文献17

  • 1Sadmeet Singh,Skanda Sadacharan,Scott Su,et al.Overexpres-sion of Vimentin:Role in the Invasive Phenotype in an Androgen-independent Model of Prostate Cancer[J].Cancer Res,2003,63(9):2306.
  • 2Vasko V,Espinosa AV,Scouten W,et al.Gene expression andfunctional evidence of epithelial-to-mesenchymal transition in pa-pillary thyroid carcinoma invasion[J].Proc Natl Acad Sci USA,2007,104(8):2803.
  • 3Tut VM,Braithwaite KL,Angus B,et al.Cyclin D1expression intransitional cell carcinoma of the bladder:correlation with p53,wsf1,pRb and Ki 67[J].Br J Cancer,2001,84(2):270.
  • 4Osborn M,Weber K.Intermediate filaments:cell-type specificmarkers in the differentiation and pathology[J].Cell,1982,31:303.
  • 5Rodríguez-Pinilla SM,Sarrio D,Honrabo E,et al.Vimentin andlaminin expression is associated with basal-like phenotype in bothsporadic and BRCA1-associated breast carcinomas[J].J ClinPathol,2007,60(9):1006.
  • 6Kim KR,Choi HN,Lee HJ,et al.A peroxisome proliferator-acti-vated receptor gamma antagonist induces vimentin cleavage andinhibits invasion in high-grade hepatocellular carcinoma[J].OncolRep,2007,18(4):825.
  • 7Williams AA,Higgins JP,Zhao H,etal.CD9and vimentin dis-tinguish clear cell from chromophobe renal cell carcinoma[J].BMC Clin Pathol,2009,9:9.
  • 8Perlson E,Michaelevski I,Kowalsman N,et al.Vimentin bind-ing to phosphorylated Erk sterically hinders enzymatic dephos-phorylation of the kinase[J].J Mol Biol,2006,364(5):938.
  • 9Ueda M,Terai Y,Kumagai K,et al.Correlation between tumorangiogenesis and expression of thymidine phosphorylase,and pa-tient outcome in uterine cervical carcinoma[J].Hum Pathol,1999,30(11):1389.
  • 10Chang L,Goldman RD.Intermediate filaments mediate cytoskele-tal crosstalk[J].Nat Rev Mol Cell Bio,2004,5(4):601.

引证文献3

二级引证文献5

中国实验诊断学
2011年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部