新疆维族胆固醇结石患者肝组织SCP2蛋白的表达

Expression of Sterol Carrier Protein2 Gene in Patients with Cholesterol Gallstone of Uygur Nationality in Xinjiang

目的研究新疆维族胆囊胆固醇结石患者与汉族胆固醇结石患者、维族非结石患者肝组织SCP2的表达情况和血脂变化。方法应用Western blot技术,研究新疆维族胆囊胆固醇结石患者、汉族胆固醇结石结石患者和维族非结石患者各20例肝组织SCP2的蛋白表达水平差异;并采用生物化学技术检测其血脂改变。结果维族与汉族胆囊胆固醇结石患者肝组织SCP2蛋白表达水平无显著差异,维族胆囊胆固醇结石患者肝组织SCP2蛋白表达水平较维族非结石组升高,差异有显著性;各组间血脂无显著性差别。结论新疆维族胆囊胆固醇结石患者肝组织SCP2蛋白水平升高,SCP2表达上调可能是胆囊胆固醇结石形成的重要原因。

Objective To investigate the expression level of liver SCP2 in Uygur and han Nationality cholesterol gallstone patients and Uygur Nationality patients without gallstones in Xinjiang and changes of serum lipid levels.Methods The expression level of liver SCP2 protein was studied in 20 Uygur Nationality patients and 20 han Nationality patients with cholesterol gallstone and 20 Uygur Nationality patients without gallstones by Western blot method;the serum lipid levels were also determined by biochemical techniques.Results There were no significant differences between 20 Uygur Nationality patients and 20 han Nationality patients with cholesterol gallstone,however,The expression of SCP2 protein was increased significantly in cholesterol gallstone patients of Uygur Nationality as compared with non-gallstone patients of Uygur Nationality.There were no significant differences between the serum lipid levels of the three groups.Conclusion SCP2 gene was overexpressed in cholesterol gallstone patients of Uygur Nationality in Xinjiang,indicating that SCP2 maybe one of the important etiologic causes of cholesterol gallstones.