高血压与骨质疏松发病机制中细胞因子的变化

Change of Cytokines in the Pathogenesis of Hypertension and Osteoporosis

在高血压病、骨质疏松的进展中,免疫系统的激活起重要作用,白细胞介素6、肿瘤坏死因子、C反应蛋白、集落刺激因子等细胞因子参与其中。细胞因子通过自分泌和旁分泌作用,影响成骨细胞和破骨细胞的分化、增殖和成熟;而C反应蛋白等位基因的变异性与高血压密切相关。细胞因子对早期预防和治疗高血压与骨质疏松有重要的临床意义。

The activation of immune system play important roles in the progression of hypertension and osteoporosis,including of cytokines IL-6,TNF,CRP,CSF and etc.Cytokines affect cell differentiation,generation and maturation of osteoblast and osteoclast by autocrine and paracrine,while the variability of CRP allele is closely related to essential hypertension.Cytokines is very important in prevention and treatment of hypertension and osteoporosis in early period.