组织工程血管高分子生物支架研究进展

Study of Polymer Scaffold Materials for Tissue-engineered Blood Vessels

可替代自体血管的组织工程血管已应用于心血管疾病临床治疗。传统人工血管免疫排斥、吻合口增生、血栓等因素阻碍其临床应用与发展。随着组织工程血管技术的发展,高分子生物支架赋予人工血管再生潜能,即种子细胞的种植、黏附、增殖,随之支架适时降解,最终新血管形成。可见,组织工程血管的发展需要良好组织相容性高分子生物支架材料及新型支架制作技术。现就近年来组织工程血管高分子生物支架材料及制作工艺研究新进展予以综述。

Tissue-engineered blood vessels replacing autologous blood vessels have been used in the clinical treatment for cardiovascular disorders.Immune rejections,anastomotic hyperplasia,and thrombosis impair the clinical use and development of conventional artificial blood vessels.With the technolgoical development of tissue-engineered blood vessels,polymer biomaterial scaffolds render the regenerative potential of artificial blood vessels,namely,the seeding,adhesion,and proliferation of seed cells degrade the scaffolds in an appropriate manner,resulting in the neoangiogenesis.It is concluded that the development of tissue-engineered blood vessels requires a high histocompatible polymer bioscaffold material and a new scaffold preparation technique.This article reviews the advances in tissue-engineered polymer bioscaffold material and scaffold preparation technique.