果糖及其相关溶媒的合理应用

Good Use of Fructose and Solvents

果糖是一种葡萄糖的同分异构体,与葡萄糖相比,它不经过磷酸葡萄糖变位酶而直接转化成糖原。短期低剂量使用时,对血糖代谢和胰岛素功能无影响,临床上常作为溶媒应用于糖尿病患者。然而,长期大剂量使用却容易诱发高尿酸血症、乳酸酸中毒、代谢综合征和静脉炎等。此外,果糖与多种碱性药物配伍时,其多羟基酮因裂解而导致稳定性下降。正确掌握果糖及其相关溶媒的适应证和配伍特点,有助于提高用药安全性。

Fructose is an isomer of glucose.In contrast to glucose,fructose can be directly converted into glycogen in the absence of phosphoglycerate mutase.The short-term low-dose use of fructose has minimal effect on glucose metabolism and insulin function.Therefore,fructose is frequently used as solvents for diabetic patients.However,the long-term high-dose use of fructose is subject to hyperuricemia,lactic academia,metabolic syndrome,and phlebitis.Additionally,fructose is incompatible with multiple alkaline agents,showing the reduced stability due to the cleavage of polyhydroxyl ketone.The proper understanding of indications and admixture properties of fructose and solvents will help to improve the safety profile of medication.