松针叶绿素-胡萝卜素软膏对实验性胃溃疡的防治作用

Effects of Chlorophyll-carotene Paste from Pine Needles on Experimental Gastric Ulcer

采用幽门结扎致大鼠胃溃疡模型、乙醇致大鼠胃溃疡模型和醋酸致大鼠胃溃疡模型进行实验,通过测定胃溃疡面积计算3种模型的胃溃疡抑制率,考察了幽门结扎大鼠的胃液及胃蛋白酶活性和大鼠醋酸型胃溃疡病理切片,从而研究了松针叶绿素-胡萝卜素软膏的抗胃溃疡作用。结果表明:松针叶绿素-胡萝卜素软膏0.75、1.50和2.25 g/kg 3个剂量组均能显著抑制胃液分泌量,升高胃酸pH值,抑制胃蛋白酶活性(P<0.01),对大鼠幽门结扎型、乙醇型和醋酸型胃溃疡均有显著的抑制作用(P<0.01),其中2.25 g/kg剂量组的抑制率分别为84.39%、65.33%和80.68%,显示松针叶绿素-胡萝卜素软膏对实验性胃溃疡具有预防和治疗作用。

Gastritis models induced by pyloric ligation, ethanol and acetic acid in rats were used to investigate the anti-gastric ulcer action of chlorophyll-carotene paste from pine needles. The gastric ulcer area, gastric juice quantity, pH value, pepsin activity were measured and pathological slices were examined. The results showed that chlorophyll-carotene paste from pine needles groups with different dosages of 0.75, 1.50 and 2.25 g/kg inhibited gastric secretion, increased gastric juice pH value and decreased pepsin activity remarkably（ P 〈0.01 ） , It also greatly inhibited the formation of gastric ulcers induced by pylorie ligation, ethanol and acetic acid（ P 〈 0.01 ）. The inhibitory rates at the dosage of 2.25 g/kg were 84.39 % , 65.33 % and 80.68 % respectively. It was seen that Chlorophyll-carotene paste from pine needles had preventive and therapeutic effects on experimental gastric ulcer.