摘要
研究了一种简便的、易于工业化的制备1,8-辛二醇的新方法。以1,8-辛二腈为原料,先在硫酸催化下和甲醇反应高收率地得到辛二酸二甲酯,接着辛二酸二甲酯在硼氢化钠-甲醇-四氢呋喃体系中还原得到产物1,8-辛二醇,重点考察了还原剂硼氢化钠用量及反应时间对1,8-辛二醇收率的影响,得到了较佳的工艺条件:硼氢化钠与辛二酸二甲酯的物质的量之比为5.5∶1,反应时间为8.5 h,此条件下1,8-辛二醇收率97.2%。
A convenient and industrializable new method of synthesizing 1,8-octanediol was studied. 1,8-Octanedioic acid dimethyl ester was obtained at high yield, using hexamethylene dicyanide and methanol as raw material catalyzed by concentrated sulfuric acid, followed by the reduction of 1,8-octanedioic acid dimethyl ester via sodium borohydride in a NaBH4-methanol- tetrahydrofuran solvent system to obtain 1,8-octanedinl. Effects of the amount of NaBH4 and reaction time on the overall yield of 1,8-octanediol were investigated. The optimum reaction conditions were as follows： molar ratio of NaBH4 to 1,8-octanedioic acid dimethyl ester 5 ： 5.1, reaction time 8.5 h, the yield of 1,8-octanediol was 97.2 %.
出处
《林产化学与工业》
EI
CAS
CSCD
北大核心
2011年第1期105-108,共4页
Chemistry and Industry of Forest Products
