摘要
应用新研制的^(99m)Tc—ECD 配套药盒进行初步临床研究,结果表明:制备方法简便,性能稳定,标记率97.20±0.02%,血液清除迅速,T1/2α24.75min,T1/2β11.55h;注药后5min 脑内放射性达7.75% ID,30min 达高峰(7.95% ID),脑内生物半衰期>10h;2h 尿排量57.57% ID,尚可经胆道排泄。SPECT 脑血流断层显像清晰,病灶易辨,对比度高,未发现有不良反应。说明^(99m)Tc—ECD 是目前诊断脑缺血性病变的一种新型脑血流显像剂。
This paper reports the preliminary clinical study of the new ^(99m)Tc-ECD kits.Thefollowing results were obtained:(1)The labeling method was simple with a labelin grate of 97.2±0.02% and the labelled compound was stable in vitro;(2)The clearanc eof ^(99m)Tc-ECD in blood was rapid for which T-alpha_(1/2)is 24.75 min and T-beta_(1/2)11.55 h;(3)The brain radioactvity was 7.75%I.D.at 5 min after I.V.injection anda peak was reached at the point of 7.95% I.D.30 min after injection and biologi-cal half life was more than 10 hours;(4)57.57% of imaging agents I.D.was clearedaway through urine during the first 2 hours after I.V.injection,and it could be alsoexcreted through the biliary passage;(5)The image quality of cerebral blood flowtomography using ^(99m)Tc-ECD was excellent and the cerebral lesion were displayedclearly.The authors conclude that this new cerebral blood flow imaging agent is ofgreat practical value for the diagnosis of cerbral ischemia diseases.
出处
《苏州医学院学报》
1990年第4期278-281,341+346,共4页
Acta Academiae Medicinae Suzhou