新型脑血流显像剂^(99m)Tc—ECD的初步临床研究

The Preliminary Clinical Study of ^(99m)Tc-ECD(A New Cerebral Blood Flow Imaging Agent)

应用新研制的^(99m)Tc—ECD 配套药盒进行初步临床研究,结果表明:制备方法简便,性能稳定,标记率97.20±0.02%,血液清除迅速,T1/2α24.75min,T1/2β11.55h;注药后5min 脑内放射性达7.75% ID,30min 达高峰(7.95% ID),脑内生物半衰期>10h;2h 尿排量57.57% ID,尚可经胆道排泄。SPECT 脑血流断层显像清晰,病灶易辨,对比度高,未发现有不良反应。说明^(99m)Tc—ECD 是目前诊断脑缺血性病变的一种新型脑血流显像剂。

This paper reports the preliminary clinical study of the new ^(99m)Tc-ECD kits.Thefollowing results were obtained:(1)The labeling method was simple with a labelin grate of 97.2±0.02% and the labelled compound was stable in vitro;(2)The clearanc eof ^(99m)Tc-ECD in blood was rapid for which T-alpha_(1/2)is 24.75 min and T-beta_(1/2)11.55 h;(3)The brain radioactvity was 7.75%I.D.at 5 min after I.V.injection anda peak was reached at the point of 7.95% I.D.30 min after injection and biologi-cal half life was more than 10 hours;(4)57.57% of imaging agents I.D.was clearedaway through urine during the first 2 hours after I.V.injection,and it could be alsoexcreted through the biliary passage;(5)The image quality of cerebral blood flowtomography using ^(99m)Tc-ECD was excellent and the cerebral lesion were displayedclearly.The authors conclude that this new cerebral blood flow imaging agent is ofgreat practical value for the diagnosis of cerbral ischemia diseases.