氟苯尼考的研究进展及临床应用

Advance in the Research and Clinical Application of Florfenicol

氟苯尼考是氯霉素类广谱抗菌药,广泛应用于畜牧业和水产养殖业生产上,随着使用范围的扩大,其在药效学和药物代谢动力学方面已有了广泛研究。该文主要介绍了氟苯尼考的理化性质、抗菌机理、药效学、药物代谢动力学及联合抗药性,概括了氟苯尼考的常用检测方法和在常见动物体内的应用。

Florfenicol is a broad-spectrum antimicrobial which was widely used in aquaculture and livestock.It belonged to Chloramphenicol class.With the expanding usage,it had been widely studied on pharmacodynamics and pharmacokinetics. The main content in this article involved the physical and chemical properties,antibacterial mechanism,pharmacodynamics, pharmacokinetics and joint resistance of florfenicol,its common detection methods and the application for animals.