甘肃棘豆对家兔血液生化指标的影响

Toxicity of Oxytropis kansuensis Towards Rabbits

将18只健康成年家兔随机分为3个组,每天分别按每千克体重1、5、10 g剂量饲喂甘肃棘豆,并在试验前及试验后每隔14 d测定血液生化指标,探索甘肃棘豆对实验家兔的毒性。结果表明,在试验第18天Ⅲ组1只怀孕母兔流产,Ⅱ和Ⅲ组试验家兔在第35天开始出现甘肃棘豆中毒症状,Ⅰ组试验家兔在整个试验期间没有出现异常表现;3个试验组家兔血清AKP、GOT活性及BUN含量明显升高(P<0.05或P<0.01)且随棘豆剂量增加而增高,血清GPT活性明显下降(P<0.05或P<0.01);肌酐含量在试验期间没有明显变化(P>0.05);LDH活性从试验第14天起各试验组均明显升高(P<0.05或P<0.01),在试验第28天时均达到最高,与试验前比较差异极显著(P<0.01),随后又下降。

Eighteen healthy adult rabbits were randomly divided into three groups,and were fed with O.kansuensis respectively at 1 g/（kg·d-1）and 5 g/（kg·d-1）and10 g/（kg·d-1）,and Blood biochemical indicators were tested before the experiment and interval 14 days after experimental,to study the toxicity of O.kansuensis towards rabbits.The results showed that an pregnant females of group Ⅲ was abortioned in 18th day,and rabbits of group Ⅱand group Ⅲ were appeared O.kansuensis poisoning symptans in 35th day,and rabbits of groupⅠdoes not appeared abnormal performance in the period of experiment.In the al1 test period,the AKP,GOT activity and BUN content inereased（P0.05 or P0.01）,and GPT activity decreased obviously（P0.05 or P0.01）.No significant changes in CRE content in the period of experiment.LDH activity was increased significantly from 14th to 28th（P0.01） and then returned in every group during experiment.