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APE1单核苷酸多态性与肺癌易感性关系的研究 被引量：2

Association of single nucleotide polymorphism of APE1 gene with susceptibility to lung cancer
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摘要 目的探讨中国重庆汉族人群脱嘌呤/脱嘧啶核酸内切酶1(APE1)基因单核苷酸多态性与肺癌易感性的关系。方法采用病例对照研究,应用相对的两对引物-聚合酶链反应(PCR-CTPP)技术检测455例肺癌患者和443例健康人APE1-141T/G和APE1 148Asp/Glu单核苷酸多态性(SNP)。结果 APE1-141G/G基因型相对于T/T基因型,显著减少了患肺癌的风险(OR=0.62;95%CI为0.42～0.91);单倍体分析中,APE1-141T/148Glu单倍体相对于-141T/148Asp单倍体,显著增加了患肺癌的风险(OR=1.28,95%CI为1.01～1.62)。结论 APE1基因与中国重庆汉族人群肺癌易感性密切相关,APE1-141T/148Glu单倍体可能是肺癌的重要遗传易感因素。 Objective To explore the genetic association between the single nucleotide polymorphism（SNP） of APE1 gene and the susceptibility to lung cancer among Chinese Han people in Chongqing.Methods A population based case control study was conducted in 443 healthy controls and 445 lung cancer patients.The SNP of APE1―141T/G and APE1 148Asp/Glu were detected by polymerase chain reaction with confronting two-pair primers（PCR-CTPP）.Results For the APE1 ―141T/G polymorphism,individuals with G/G genotype significantly decreased the risk of developing lung cancer compared with those harboring T/T genotype（OR=0.62;95%CI,0.42―0.91）and APE1 ―141T/148Glu haplotype markedly increased the risk,compared to ―141T/148Asp haplotype（OR=1.28;95%CI：1.01―1.62）,according to haplotype analysis.Conclusion This study confirms the close relationship between APE1 gene and Lung cancer.APE1 ―141T/148Glu haplotype may serves as an important genetic susceptibility factor for lung cancer.
作者 李峥 李梦侠 廖玲 王东
机构地区 第三军医大学大坪医院野战外科研究所肿瘤中心
出处 《重庆医学》 CAS CSCD 北大核心 2011年第6期528-531,共4页 Chongqing medicine
基金 国家自然科学基金资助项目(30670628)
关键词 肺肿瘤 脱嘌呤/脱嘧啶核酸内切酶1 单核苷酸多态性 lung neoplasm apurinic/apyrimidinic endonuclease 1 single nucleotide polymorphism
分类号 R734.2 [医药卫生—肿瘤]
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参考文献16

  • 1Kurzepa-Hasan E,Hasan K,Adamek R.Tobacco smoking among population in the United Kingdom of Great Britain and Northern Ireland between years:1950 and 2003[J].Przegl Lek,2008,65(10):740-741.
  • 2Andersson U,McKean-Cowdin R,Hjalmars U,et al.Genetic variants in association studies--review of strengths and weaknesses in study design and current knowledge of impact on cancer risk[J].Acta Oncol,2009,48(7):948-954.
  • 3Tudek B.Base excision repair modulation as a risk factor for human cancers[J].Mol Aspects Med,2007,28(3-4):258-275.
  • 4Lo YL,Jou YS,Hsiao CF,et al.A polymorphism in the APE1 gene promoter is associated with lung cancer risk[J].Cancer Epidemiol Biomarkers Prev,2009,18(1):223-229.
  • 5Lu J,Zhang S,Chen D,et al.Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility[J].FASEB J,2009,23(10):3459-3469.
  • 6Demple B,Sung JS.Molecular and biological roles of Ape1 protein in mammalian base excision repair[J].DNA Repair,2005,4(12):1442-1449.
  • 7Tell G,Damante G,Caldwell D,et al.The intracellular location of APE1/Ref-1:more than a passive phenomenon[J].Antioxidants and Redox Signaling,2005,7(3):367-384.
  • 8Hung RJ,Hall J,Brennan P,et al.Genetic polymorphisms in the base excision repair pathway and cancer risk:a HuGE review[J].Am J Epidemiol,2005,162:925-942.
  • 9El-Domyati M,Attia S,Saleh F,et al.Proliferation,DNA repair andapoptosis in androgenetic alopecia[J].J Eur Acad Dermatol Venereol,2009,23(1):7-12.
  • 10Xi T,Jones IM,Mohrenweiser HW.Many amino acid substitution variants identified in DNA repair genes during human population screenings are predicted to impact protein function[J].Genomics,2004,83:970-979.

同被引文献36

  • 1Tikhmyanova N,Little JL,Golemis EA.CAS proteins in normal and pathological cell growth control[J].Cell Mol Life Sci,2010,67(7):1025-1048.
  • 2Kanner SB,Reynolds AB,Parsons JT.Tyrosine phospho-rylation of a120-kilodalton pp60src substrate upon epi-dermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-anti-gen-transformed cells[J].Mol Cell Biol,1991,11(2):713-720.
  • 3Sakai R,Iwamatsu A,Hirano N,et al.A novel signaling molecule,p130,forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner[J].EMBO J,1994,13(16):3748-3756.
  • 4Brinkman A,van der Flier S,Kok EM,et al.BCAR1,a human homologue of the adapter protein p130CAS,and antiestrogen resistance in breast cancer cells[J].J Natl Cancer Inst,2000,92(2):112-120.
  • 5Kirsch KH,Georgescu MM,Hanafusa H.Direct binding of p130(Cas)to the guanine nucleotide exchange factor C3G[J].J Biol Chem,1998,273(40):25673-25679.
  • 6Vuori K,Hirai H,Aizawa S,et al.Introduction of p130CAS signaling complex formation upon integrin-mediated cell adhesion:a role for Src family kinases[J].Mol Cell Biol,1996,16(6):2606-2613.
  • 7Nasertorabi F,Tars K,Becherer K,et al.Molecular basis for regulation of Src by the docking protein p130CAS[J].J Mol Recognit,2006,19(1):30-38.
  • 8Hoon Kim D,Jeon Choi S,Kook S,et al.Phosphorylation-dependent cleavage of p130CAS in apoptotic rat-1cells[J].Biochem Biophys Res Commun,2003,300(1):141-148.
  • 9Nakamoto T,Sakai R,Honda H,et al.Requirements for localization of p130CAS to focal adhesions[J].Mol Cell Biol,1997,17(7):3884-3897.
  • 10Meenderink LM,Ryzhova LM,Donato DM,et al.P130CAS Src-binding and substrate domains have distinct roles in sustaining focal adhesion disassembly and promoting cell migration[J].Plos One,2010,5(10):13412.

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重庆医学
2011年 第6期

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