IRAK-4在白介素-1受体/Toll样受体(IL-1R/TLRs)介导的炎症信号通路中的关键作用

The key function of IRAK-4 in the inflammation signal pathway mediated by Toll-like receptors

白介素-1受体相关激酶4(interleukin-1 receptor-associated kinase 4;IRAK-4)是近年来发现的参与机体先天性免疫反应过程中的关键分子。它与另外3个成员IRAK-1、IRAK-2、IRAK-M同属于IRAK家族,目前经过对IRAK-4分子的激酶活性以及其对炎症反应的正向和负向的调控作用的研究表明,IRAK-4分子联系着上下游的信号转导,在TLRs/IL-1R介导的炎症信号通路中的作用更为关键。本文就IRAK-4分子的活性、以及IRAK-4分子在TLRs/IL-1R介导的炎症信号转导通路中的作用作一综述。以期设计出针对IRAK-4特异性的药物,或者通过基因治疗手段干预IRAK-4表达,为感染控制提供新的思路,开发出新的抗炎药物。

interleukin-I receptor - associated kinase 4 （IRAK-4） is a key molecular which participates in the innate immune processes. It belongs to the IRAK family with the other three members： IRAK-1 , IRAK-2, and IRAK-M. However, It has been found that IRAK-4 plays a more important role in the inflammatory signal pathway mediated by TLRs/IL-1Rs through the deep investigation of the IRAK-4 kinase activity and the positive/negative regulation mechanism of the inflammatory reactions. The activities of IRAK-4 and the crucial function of IRAK4 in the TLRs/IL-1Rs mediated pathways of inflammatory signal transmission were summarized.