载脂蛋白(a)亚型与脑梗塞的病因学联系

SERUM LIPOPROTEIN(a) AND APOLIPOPROTEIN(a) PHENOTYPE IN PATIENTS WITH CEREBRAL INFARCTION

为探讨 Ｌｐ（ａ）、ａｐｏ（ａ）与脑梗塞病因学的关系，阐明ａｐｏ（ａ）基因表型对脑梗塞的调控作用，检测了 ９０ 例经 Ｃ Ｔ 确诊的脑梗塞患者血清 Ｌｐ（ａ）含量，并分离出 １３ 种 ａｐｏ（ａ）表型，与对照（以年龄、性别配比）比较。结果表明，高 Ｌｐ（ａ）者（≥３０ｍ ｇ／ｄｌ）患脑梗塞的危险性为正常者（＜ ３０ｍ ｇ／ｄｌ）的 ３５６ 倍（ Ｐ＜ ０．０１），ａｐｏ（ａ）分子量与 Ｌｐ（ａ）水平呈高度负相关，ｒ＝ － ０．４８１，说明 ａｐｏ（ａ）大小决定了约 ４８％ 的 Ｌｐ（ａ）水平。ａｐｏ（ａ）等位基因 Ｌｐ Ｂ、 Ｌｐ Ｓ１、 Ｌｐ Ｓ２ 可能是易发脑梗塞者的基因标志。

The serum lipoprotein(a) and evaluated apolipoprotein(a) phenotypes in 90 patients with cerebral infarction(CI) were measured. 90 age and sex matched control were also been studied. The result revealed that subjects with a higher level of Lp(a)(≥30mg/dl) were increased in risk than that in normal ones(<30mg/dl)(P<0.01). Thirteen apo(a) bands were separated and a highly significant inverse correlation was found between apo(a) molecular weight (MW) and serum Lp(a) levels (R=-0.481,P<0.01). In each phenotype, Lp(a) levels were significantly higher in CI patients than that in controls. Overall, phenotypes with lower MW often associated with high Lp(a) levels,such as B、S 1、S 2,and these were more prevalent in patients than that in controls. The alleles LpB、Lps 1、Lps 2 could probably be predisposing genetic markers for cerebral infarction.